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Titolo:
Strain differences in the isolation-induced effects on prepulse inhibitionof the acoustic startle response and on locomotor activity
Autore:
Weiss, IC; Di Iorio, L; Feldon, J; Domeney, AM;
Indirizzi:
Swiss Fed Inst Technol, Behav Neurobiol Lab, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 2, volume: 114, anno: 2000,
pagine: 364 - 373
SICI:
0735-7044(200004)114:2<364:SDITIE>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS; SOCIAL-ISOLATION; OPEN-FIELD; SCHIZOPHRENIC-PATIENTS; INCREASED SENSITIVITY; ANTIPSYCHOTIC-DRUGS; INDUCED DEFICITS; RAT STRAINS; IN-VIVO; APOMORPHINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Feldon, J Swiss Fed Inst Technol, Behav Neurobiol Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schorenstr 16 Schwerzenbach Switzerland CH-8603
Citazione:
I.C. Weiss et al., "Strain differences in the isolation-induced effects on prepulse inhibitionof the acoustic startle response and on locomotor activity", BEHAV NEURO, 114(2), 2000, pp. 364-373

Abstract

The authors investigated the effects of isolation rearing on acoustic startle response, prepulse inhibition (PPI), its modification by apomorphine, and locomotor activity in 3 rat strains: Wistar (WS), Sprague-Dawley (SD), and Lister hooded (LH). SD and LH, but not WS. showed isolation-induced PPI deficits. In 2 consecutive PPI tests, only SD isolates showed significant PPI deficits. An isolation rearing effect in LH was significant only. in theIbt PPI test. Apomorphine dose-dependently (0.0-0.5 mg/kg) disrupted PPI. but sensitivity to the drug differed, with WS and SD rats being more sensitive to lower doses (0.01-0.05 mg/kg) than LH rats (0.5 mg/kg). Isolates, irrespective of strain, did not differ from grouped rats in their response tothe apomorphine challenge. Only WS and LH isolates demonstrated significantly increased locomotor activity. Strain differences in the different parameters measured did not predict isolation-induced effects on PPI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:49:12