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Titolo:
Polymorphism at NRAMP1 and D2S1471 loci associated with juvenile rheumatoid arthritis
Autore:
Sanjeevi, CB; Miller, EN; Dabadghao, P; Rumba, I; Shtauvere, A; Denisova, A; Clayton, D; Blackwell, JM;
Indirizzi:
Karolinska Hosp, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 Hosp, S-10401 Stockholm, Sweden Univ Cambridge, Sch Clin Med, Cambridge, England Univ Cambridge Cambridge England idge, Sch Clin Med, Cambridge, England Med Acad Latvia, Riga, Latvia Med Acad Latvia Riga LatviaMed Acad Latvia, Riga, Latvia Univ Forvie Site, Inst Publ Hlth, Cambridge, England Univ Forvie Site Cambridge England , Inst Publ Hlth, Cambridge, England
Titolo Testata:
ARTHRITIS AND RHEUMATISM
fascicolo: 6, volume: 43, anno: 2000,
pagine: 1397 - 1404
SICI:
0004-3591(200006)43:6<1397:PANADL>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; CANDIDATE GENES NRAMP1; EASTERN BALTIC REGION; NATURAL-RESISTANCE; DISEASE SUSCEPTIBILITY; RESPONSE CRITERIA; EM ALGORITHM; HLA; LINKAGE; MACROPHAGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Blackwell, JM Addenbrookes Hosp, Wellcome Trust Ctr, Study Mol Mechanisms Dis, CambridgeInst Med Res, Wellcome Trust MRC Bldg,Hills Rd, Cambridge CB22XY, England Addenbrookes Hosp Wellcome Trust MRC Bldg,Hills Rd CambridgeEngland CB2 2XY
Citazione:
C.B. Sanjeevi et al., "Polymorphism at NRAMP1 and D2S1471 loci associated with juvenile rheumatoid arthritis", ARTH RHEUM, 43(6), 2000, pp. 1397-1404

Abstract

Objective. To examine the role of NRAMP1 in susceptibility to juvenile rheumatoid arthritis (JRA),Methods. DNA from 119 JRA patients (72 pauciarticular, 47 polyarticular) and 111 healthy controls from Latvia was genotyped for a functional repeat polymorphism in the promoter of NRAMP1 and a linked (<150 kb) microsatelliteDS1471. The findings were compared with those from HLA-DQ alleles typed previously, Chi-square analyses were performed using the Mantel-Haenszel testand stratification according to pure Latvian or pure Russian descent. Haplotype analysis was performed using the Associate program to implement the expectation-maximization algorithm based on the gene-counting technique. Results. Allele 3 at NRAMP1 conferred increased risk (odds ratios [ORs] 2.26, 2.31, and 2.19; P = 0.0006, 0.003, and 0.019) of disease in the JRA, pauciarticular, and polyarticular patient groups, respectively, Allele 2 conferred protection (OR 0.44, 0.43, and 0.46). Alleles at D2S1471 that conferred susceptibility (6 and 12) or protection (11) did so only when on a haplotype with alleles 3 or 2, respectively, at NRAMP1. Allele 3 at NRAMP1 was additive with HLA-DQ7 for susceptibility (OR 3.71, 3.71, and 4.02), and allele 2 at NRAMP1 was additive with HLA-DQ5 for protection (OR 0.19, 0.08, and0.12). Conclusion. The NRAMP1 allele conferring susceptibility to JRA drives highlevels of NRAMP1 expression, while the allele associated with protection drives low levels, These 2 alleles are inversely associated,vith susceptibility to infectious disease, consistent,with their maintenance in populationsthrough balancing selection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:31:04