Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
Autore:
Hotta, K; Funahashi, T; Arita, Y; Takahashi, M; Matsuda, M; Okamoto, Y; Iwahashi, H; Kuriyama, H; Ouchi, N; Maeda, K; Nishida, M; Kihara, S; Sakai, N; Nakajima, T; Hasegawa, K; Muraguchi, M; Ohmoto, Y; Nakamura, T; Yamashita, S; Hanafusa, T; Matsuzawa, Y;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Mol Sci, Suita, Osaka 5650871, Japan Toyonaka City Hosp, Osaka, Japan Toyonaka City Hosp Osaka JapanToyonaka City Hosp, Osaka, Japan ITOCHU Corp, Dept Hlth Adm, Osaka, Japan ITOCHU Corp Osaka JapanITOCHU Corp, Dept Hlth Adm, Osaka, Japan Otsuka Pharmaceut Co Ltd, Cellular Technol Inst, Tokushima 77101, Japan Otsuka Pharmaceut Co Ltd Tokushima Japan 77101 t, Tokushima 77101, Japan
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 6, volume: 20, anno: 2000,
pagine: 1595 - 1599
SICI:
1079-5642(200006)20:6<1595:PCOANA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; PLASMINOGEN-ACTIVATOR INHIBITOR; INSULIN-RESISTANCE; VASCULAR-DISEASE; VISCERAL FAT; OBESITY; LEPTIN; TISSUE; EXPRESSION; MELLITUS;
Keywords:
adiponectin; diabetes mellitus; coronary artery disease; adipose tissue;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Hotta, K Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan5650871 5650871, Japan
Citazione:
K. Hotta et al., "Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients", ART THROM V, 20(6), 2000, pp. 1595-1599

Abstract

Adiponectin is a novel, adipose-specific protein abundantly present in thecirculation, and it has antiatherogenic properties. We analyzed the plasmaadiponectin concentrations in age- and body mass index (BMI)-matched nondiabctic and type 2 diabetic subjects with and without coronary artery disease (CAD). Plasma levels of adiponectin in the diabetic subjects without CAD were lower than those in nondiabetic subjects (6.6+/-0.4 versus 7.9+/-0.5 mu g/mL in men, 7.6+/-0.7 versus 11.7+/-1.0 mu g/mL in women; P<0.001). The plasma adiponectin concentrations of diabetic patients with CAD were lower than those of diabetic patients without CAD (4.0+/-0.4 versus 6.6+/-0.4 mu g/mL, P<0.001 in men; 6.3 +/-0.8 versus 7.6+/-0.7 mu g/mL in women). In contrast, plasma levels of leptin did not differ between diabetic patients with and without CAD. The presence of microangiopathy did not affect the plasma adiponectin levels in diabetic patients. Significant, univariate, inversecorrelations were observed between adiponectin levels and fasting plasma insulin (r= -0.18, P<0.01) and glucose (r= -0.26, P<0.001) levels. In multivariate analysis, plasma insulin did not independently affect the plasma adiponectin levels. BMI, serum triglyceride concentration, and the presence ofdiabetes or CAD remained significantly related to plasma adiponectin concentrations. Weight reduction significantly elevated plasma adiponectin levels in the diabetic subjects as well as the nondiabetic subjects. These results suggest that the decreased plasma adiponectin concentrations in diabetesmay be an indicator of macroangiopathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:25:08