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Titolo:
Vascular protection - A novel nonangiogenic cardiovascular role for vascular endothelial growth factor
Autore:
Zachary, I; Mathur, A; Yla-Herttuala, S; Martin, J;
Indirizzi:
Univ London Univ Coll, Dept Med, London WC1E 6JJ, England Univ London UnivColl London England WC1E 6JJ , London WC1E 6JJ, England Univ Kuopio, AI Virtanen Inst, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 nen Inst, FIN-70211 Kuopio, Finland Univ Kuopio, Dept Med, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 Dept Med, FIN-70211 Kuopio, Finland
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 6, volume: 20, anno: 2000,
pagine: 1512 - 1520
SICI:
1079-5642(200006)20:6<1512:VP-ANN>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL ADHESION KINASE; NITRIC-OXIDE SYNTHASE; SMOOTH-MUSCLE CELLS; INTRAMUSCULAR GENE-TRANSFER; CASPASE-MEDIATED CLEAVAGE; PERMEABILITY FACTOR; THERAPEUTIC ANGIOGENESIS; RABBIT MODEL; IN-VIVO; VONWILLEBRAND-FACTOR;
Keywords:
angiogenesis; atherosclerotic; prostacyclin; nitric oxide; endothelium;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
120
Recensione:
Indirizzi per estratti:
Indirizzo: Zachary, I Univ London Univ Coll, Dept Med, 5 Univ St, London WC1E 6JJ, England Univ London Univ Coll 5 Univ St London England WC1E 6JJ ngland
Citazione:
I. Zachary et al., "Vascular protection - A novel nonangiogenic cardiovascular role for vascular endothelial growth factor", ART THROM V, 20(6), 2000, pp. 1512-1520

Abstract

There is widespread interest in the use of the angiogenic cytokine, vascular endothelial growth factor (VEGF), for the treatment of cardiovascular disease. The main paradigm for VEGF cardiovascular therapy is the stimulationof "therapeutic angiogenesis" in ischemic myocardial and peripheral vascular limb disease. In this review, approaches to VEGF therapy based on the therapeutic angiogenesis model are critically assessed, and the alternative mechanism of vascular protection is advanced. Vascular protection is definedas the VEGF-induced enhancement of endothelial functions that mediate the inhibition of vascular smooth muscle cell proliferation, enhanced endothelial cell survival, suppression of thrombosis, and anti-inflammatory effects. VEGF-induced synthesis of NO and prostacyclin are both likely to be key mediators of VEGF-dependent vascular protection. Investigation into vascular protection should help us to gain insight into the underlying mechanisms ofthe cardiovascular actions of VEGF and should prove valuable in the development of novel therapeutic approaches based on local VEGF gene delivery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 03:04:33