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Titolo:
Prognostic relevance of Masaoka and Muller-Hermelink classification in patients with thymic tumors
Autore:
Lardinois, D; Rechsteiner, R; Lang, H; Gugger, M; Betticher, D; von Briel, C; Krueger, T; Ris, HB;
Indirizzi:
Univ Bern, Inst Oncol, Div Pulm Med,Inst Pathol, Dept Thorac & Cardiovasc Surg, Bern, Switzerland Univ Bern Bern Switzerland Thorac & Cardiovasc Surg, Bern, Switzerland Univ Bern, Clin Radio Oncol, Bern, Switzerland Univ Bern Bern Switzerland iv Bern, Clin Radio Oncol, Bern, Switzerland
Titolo Testata:
ANNALS OF THORACIC SURGERY
fascicolo: 5, volume: 69, anno: 2000,
pagine: 1550 - 1555
SICI:
0003-4975(200005)69:5<1550:PROMAM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTOGENETIC CLASSIFICATION; INVASIVE THYMOMAS; EPITHELIAL TUMORS; RESECTION; SUBCLASSIFICATION; CHEMOTHERAPY; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Ris, HB Univ Lausanne Hosp, Dept Surg, Rue Bugnon 46, CH-1011 Lausanne, Switzerland Univ Lausanne Hosp Rue Bugnon 46 Lausanne Switzerland CH-1011 and
Citazione:
D. Lardinois et al., "Prognostic relevance of Masaoka and Muller-Hermelink classification in patients with thymic tumors", ANN THORAC, 69(5), 2000, pp. 1550-1555

Abstract

Background. To compare the prognostic relevance of Masaoka and Muller-Hermelink classifications. Methods. We treated 71 patients with thymic tumors at our institution between 1980 and 1997. Complete follow-up was achieved in 69 patients (97%) with a mean follow up-time of 8.3 years (range, 9 months to 17 years). Results. Masaoka stage I was found in 31 patients (44.9%), stage II in 17 (24.6%), stage III in 19 (27.6%), and stage IV in 2 (2.9%). The 10-year overall survival rate was 83.5% for stage I, 100% for stage IIa, 58% for stageIIb, 44% for stage III, and 0% for stage IV. The disease-free survival rates were 100%, 70%, 40%, 38%, and 0%, respectively. Histologic classification according to Muller-Hermelink found medullary tumors in 7 patients (10.1%), mixed in 18 (26.1%), organoid in 14 (20.3%), cortical in 11 (15.9%), well-differentiated thymic carcinoma in 14 (20.3%), and endocrine carcinoma in5 (7.3%), with 10-year overall survival rates of 100%, 75%, 92%, 87.5%, 30%, and 0%, respectively, and 10-year disease-free survival rates of 100%, 100%, 77%, 75%, 37%, and 0%, respectively. Medullary, mixed, and well-differentiated organoid tumors were correlated with stage I and II, and well-differentiated thymic carcinoma and endocrine carcinoma with stage III and IV (p < 0.001). Multivariate analysis showed age, gender, myasthenia gravis, and postoperative adjuvant therapy not to be significant predictors of overall and disease-free survival after complete resection, whereas the Muller-Hermelink and Masaoka classifications were independent significant predictorsfor overall (p < 0.05) and disease-free survival (p < 0.004; p < 0.0001). Conclusions. The consideration of staging and histology in thymic tumors has the potential to improve recurrence prediction and patient selection forcombined treatment modalities. (C) 2000 by The Society of Thoracic Surgeons.

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Documento generato il 30/11/20 alle ore 07:05:03