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Titolo:
An experimental model of chronic myocardial hibernation
Autore:
St Louis, JD; Hughes, C; Kypson, AP; DeGrado, TR; Donovan, CL; Coleman, E; Yin, BL; Steenbergen, C; Landolfo, KP; Lowe, JE;
Indirizzi:
Duke Univ, Med Ctr, Div Thorac & Cardiovasc Surg, Durham, NC USA Duke Univ Durham NC USA tr, Div Thorac & Cardiovasc Surg, Durham, NC USA Duke Univ, Med Ctr, Div Cardiol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Div Cardiol, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Radiol, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Pathol, Durham, NC 27710 USA
Titolo Testata:
ANNALS OF THORACIC SURGERY
fascicolo: 5, volume: 69, anno: 2000,
pagine: 1351 - 1357
SICI:
0003-4975(200005)69:5<1351:AEMOCM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CORONARY-ARTERY STENOSIS; BLOOD-FLOW; VENTRICULAR-FUNCTION; HEART-DISEASE; DYSFUNCTION; DOBUTAMINE; RECOVERY; REVASCULARIZATION; ECHOCARDIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: St Louis, JD Duke Univ, Med Ctr, Dept Surg, Box 3954, Durham, NC 27710 USADuke Univ Box 3954 Durham NC USA 27710 , Durham, NC 27710 USA
Citazione:
J.D. St Louis et al., "An experimental model of chronic myocardial hibernation", ANN THORAC, 69(5), 2000, pp. 1351-1357

Abstract

Background. Hibernating myocardium describes persistently impaired ventricular function at rest caused by reduced coronary blood flow. However, a realistic animal model reproducing this chronic ischemic state does not exist. The purpose of this study was to explore whether chronic low-flow hibernation could be produced in swine. Methods. Miniswine underwent 90% stenosis of the left circumflex coronary artery. Positron emission tomography and dobutamine stress echocardiographywere performed 3 and 30 days (n = 6) or 14 days (n = 4) after occlusion toevaluate myocardial blood flow and viability. Triphenyl tetrazolium chloride assessed percent infarction. Electron microscopy was used to identify cellular changes characteristic of hibernating myocardium. Results. Positron emission tomography (N-13-labeled-ammonia) 3 days after occlusion demonstrated a significant reduction in myocardial blood flow in the left circumflex distribution. This reduced flow was accompanied by increased glucose use (F-18-fluorodeoxyglucose), which is consistent with hibernating myocardium. Thirty days after occlusion, positron emission tomography demonstrated persistent low flow with increased glucose use in the left circumflex distribution. Dobutamine stress echocardiography 3 days after occlusion demonstrated severe hypocontractility at rest in the left circumflexregion. Regional wall motion improved with low-dose dobutamine followed bydeterioration at higher doses (biphasic response), findings consistent with hibernating myocardium. The results of dobutamine stress echocardiographywere unchanged 30 days after occlusion. Triphenyl tetrazolium chloride staining (n = 6) revealed a mean of 8% +/- 2% infarction of the area-at-risk localized to the endocardial surface. Electron microscopy (n = 4) 14 days after occlusion demonstrated loss of contractile elements and large areas of glycogen accumulation within viable cardiomyocytes, also characteristic of hibernating myocardium. Conclusions. Chronic low-now myocardial hibernation can be reproduced in an animal model after partial coronary occlusion. This model may prove useful in the study of the mechanisms underlying hibernating myocardium and the use of therapies designed to improve blood flow to the heart. (C) 2000 by The Society of Thoracic Surgeons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 06:08:59