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Titolo:
Impaired myogenic autoregulation in kidneys of Brown Norway rats
Autore:
Wang, XM; Ajikobi, DO; Salevsky, FC; Cupples, WA;
Indirizzi:
Sir Mortimer B Davis Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada Sir Mortimer B Davis Jewish Gen Hosp Montreal PQ Canada H3T 1E2 2, Canada Sir Mortimer B Davis Jewish Gen Hosp, Div Nephrol, Montreal, PQ H3T 1E2, Canada Sir Mortimer B Davis Jewish Gen Hosp Montreal PQ Canada H3T 1E2 2, Canada Montreal Neurol Hosp, Dept Anesthesiol, Montreal, PQ H3T 1E2, Canada Montreal Neurol Hosp Montreal PQ Canada H3T 1E2 treal, PQ H3T 1E2, Canada
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
fascicolo: 6, volume: 278, anno: 2000,
pagine: F962 - F969
SICI:
0363-6127(200006)278:6<F962:IMAIKO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL BLOOD-FLOW; FAWN-HOODED RAT; CONVERTING ENZYME-INHIBITION; TUBULOGLOMERULAR FEEDBACK; DYNAMIC AUTOREGULATION; AUTO-REGULATION; DAHL RATS; HYPERTENSION; DAMAGE; MECHANISMS;
Keywords:
renal blood flow; transfer function; dynamics; spontaneously hypertensive rat; Wistar; arginine vasopressin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Cupples, WA Sir Mortimer B Davis Jewish Gen Hosp, Lady Davis Inst Med Res,3755 Cote St Catherine Rd, Montreal, PQ H3T 1E2, Canada Sir Mortimer B Davis Jewish Gen Hosp 3755 Cote St Catherine Rd Montreal PQ Canada H3T 1E2
Citazione:
X.M. Wang et al., "Impaired myogenic autoregulation in kidneys of Brown Norway rats", AM J P-REN, 278(6), 2000, pp. F962-F969

Abstract

The Brown Norway (BN) rat is normotensive and has an extended lifespan butis extremely sensitive to hypertension-induced renal injury. Relative impairment of autoregulation has been implicated in the progression of renal failure whereas absence of myogenic autoregulation is associated with early renal failure. Therefore, we tested the hypothesis that there is conditionalfailure of renal autoregulation in BN rats. In isoflurane-anesthetized BN rats, the pressure-flow transfer function was normal when pressure fluctuated spontaneously. External forcing increased pressure fluctuation and exposed weakness of the myogenic component of autoregulation; the component mediated by tubuloglomerular feedback was less affected. In the presence of vasopressin to raise renal perfusion pressure, myogenic autoregulation was further impaired during forcing in BN rats but not in Wistar rats. Compensation by the myogenic system was rapidly restored on cessation of forcing, suggesting a functional limitation rather than a structural failure. Graded forcing in Wistar rats and in spontaneously hypertensive rats revealed that compensation due to the myogenic system was strong and independent of forcingamplitude. In contrast, graded forcing in BN rats showed that compensationwas reduced when fluctuation of blood pressure was increased but that the reduction was independent of forcing amplitude. The results demonstrate conditional failure of myogenic autoregulation in BN rats. These acute studiesprovide a possible explanation for the observed sensitivity to hypertension-induced renal injury in BN rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:27:32