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Titolo:
Effects of estrogen on venous function in rats with chronic heart failure
Autore:
Nekooeian, AA; Pang, CCY;
Indirizzi:
Univ British Columbia, Fac Med, Dept Pharmacol & Therapeut, Vancouver, BC V6T 1Z3, Canada Univ British Columbia Vancouver BC Canada V6T 1Z3 ver, BC V6T 1Z3, Canada
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 6, volume: 278, anno: 2000,
pagine: H1941 - H1947
SICI:
0363-6135(200006)278:6<H1941:EOEOVF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-INDEPENDENT RELAXATION; CIRCULATORY FILLING PRESSURE; TOTAL VASCULAR CAPACITANCE; POSTMENOPAUSAL WOMEN; NITRIC-OXIDE; MYOCARDIAL-INFARCTION; REPLACEMENT THERAPY; BLOOD-PRESSURE; PLASMA-VOLUME; L-ARGININE;
Keywords:
estradiol; mean circulatory filling pressure; arterial resistance; venous resistance; cardiac output; norepinephrine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Pang, CCY Univ British Columbia, Fac Med, Dept Pharmacol & Therapeut, 2176Hlth Sci Mall, Vancouver, BC V6T 1Z3, Canada Univ British Columbia 2176 Hlth Sci Mall Vancouver BC Canada V6T 1Z3
Citazione:
A.A. Nekooeian e C.C.Y. Pang, "Effects of estrogen on venous function in rats with chronic heart failure", AM J P-HEAR, 278(6), 2000, pp. H1941-H1947

Abstract

The effect of 17 beta-estradiol on venous function was investigated in ovariectomized rats with heart failure. Rats (50-60 days old) were ovariectomized and implanted with 60-day-release pellets that contain 17 beta-estradiol (1.5 mg) or vehicle. The left coronary artery was ligated 7 days later. Another group of ovariectomized rats was given vehicle pellets and then a sham operation was performed. The rats were studied while under pentobarbitalanesthesia at 7 wk after ligation. Ligated rats, relative to sham groups, had lower mean arterial pressure (MAP, -34 mmHg) and cardiac output (CO, -38%); higher arterial resistance (R-A, +12%) and venous resistance (R-V, +116%); mean circulatory filling pressure (MCFP, +40%) and left ventricular end-diastolic pressure (LVEDP, +11 mmHg); and similar cardiovascular responses to norepinephrine (NE). Treatment of ligated rats with 17 beta-estradiol increased CO (+16%); reduced R-A (-16%), R-V (-35%), MCFP (-23%), and LVEDP(-3 mmHg); and augmented MAP, R-V, and MCFP responses to NE. Therefore, 17beta-estradiol reduced MCFP, and this reduced preload (LVEDP). 17 beta-Estradiol decreased R-V, which, along with decreased R-A (afterload), led to an increase in CO. 17 beta-Estradiol likely augmented vasoconstriction to NEthrough an improvement on the cardiovascular status.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:54:09