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Titolo:
Carotid artery atherosclerosis in type-2 diabetic and nondiabetic subjectswith and without symptomatic coronary artery disease (the insulin resistance atherosclerosis study)
Autore:
Haffner, SM; DAgostino, R; Saad, MF; OLeary, DH; Savage, PJ; Rewers, M; Selby, J; Bergman, RN; Mykkanen, L;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Med, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 , Dept Med, San Antonio, TX 78229 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27103 USA Wake Forest Univ Winston Salem NC USA 27103 , Winston Salem, NC 27103 USA Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Tufts Univ, Sch Med, Dept Radiol, Boston, MA USA Tufts Univ Boston MA USA ufts Univ, Sch Med, Dept Radiol, Boston, MA USA NHLBI, Div Epidemiol & Clin Applicat, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 emiol & Clin Applicat, Bethesda, MD 20892 USA Univ Colorado, Sch Med, Dept Prevent Med & Biometr, Denver, CO 80202 USA Univ Colorado Denver CO USA 80202 ent Med & Biometr, Denver, CO 80202 USA Kaiser Permanente, Div Res, Oakland, CA USA Kaiser Permanente Oakland CA USA er Permanente, Div Res, Oakland, CA USA Univ So Calif, Dept Physiol & Biophys, Los Angeles, CA USA Univ So Calif Los Angeles CA USA Physiol & Biophys, Los Angeles, CA USA
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 12, volume: 85, anno: 2000,
pagine: 1395 - 1400
SICI:
0002-9149(20000615)85:12<1395:CAAITD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
AVERAGE CHOLESTEROL LEVELS; MYOCARDIAL-INFARCTION; WALL THICKNESS; HEART-DISEASE; CARDIOVASCULAR-DISEASE; GLUCOSE; WOMEN; RISK; MEN; SENSITIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Haffner, SM Univ Texas, Hlth Sci Ctr, Dept Med, 7703 Floyd Curl Dr,Mail Code 7873, SanAntonio, TX 78229 USA Univ Texas 7703 Floyd Curl Dr,Mail Code 7873 San Antonio TX USA 78229
Citazione:
S.M. Haffner et al., "Carotid artery atherosclerosis in type-2 diabetic and nondiabetic subjectswith and without symptomatic coronary artery disease (the insulin resistance atherosclerosis study)", AM J CARD, 85(12), 2000, pp. 1395-1400

Abstract

Type-2 diabetes mellitus is associated with a 2- to 4-fold increase in therisk of clinical coronary artery disease (CAD), It has been suggested thatdiabetic subjects without clinical CAD should be treated as aggressively for cardiovascular risk factors as subjects with CAD. This would be warranted if diabetic subjects without clinical CAD would have accelerated CAD similar to that of nondiabetic subjects with symptomatic CAD. To assess this suggestion, we compared the intima-media wall thickness in the common carotidartery (CCA) and internal carotid artery (ICA) in 43 diabetic subjects with clinical CAD, 446 diabetic subjects without clinical CAD, 47 nondiabetic subjects with clinical CAD, and 975 nondiabetic subjects without clinical CAD (all aged 40 to 70 years) in the Insulin Resistance Atherosclerosis Study. All data were adjusted for age, gender, ethnicity, and clinical results. Both diabetes and CAD were associated with increased atherosclerosis in the CCA. Likewise, diabetes wets significantly associated with increased atherosclerosis in the ICA; however, CAD was not associated with ICA intima-media wall thickness. As expected, diabetic subjects with CAD had the greatestintima-media wall thickness, whereas nondiabetic subjects without CAD had the least atherosclerosis. Subjects with diabetes but without CAD had slightly greater intima-media wall thickness than nondiabetic subjects with CAD,although these differences were not statistically significant. Thus, diabetic subjects even without CAD had extensive atherosclerosis in the carotid artery. These results support the suggestion that diabetic subjects should be treated as aggressively for cardiovascular risk factor management as subjects with pre-existing CAD. (C) 2000 by Excerpta Medica, Inc.

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Documento generato il 04/12/20 alle ore 16:44:32