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Titolo:
Sex differences in schizophrenia, a review of the literature
Autore:
Leung, A; Chue, P;
Indirizzi:
Univ Alberta Hosp, Dept Psychiat, Edmonton, AB T6G 2B7, Canada Univ Alberta Hosp Edmonton AB Canada T6G 2B7 Edmonton, AB T6G 2B7, Canada Univ Alberta Hosp, Psychopharmacol Res Unit, Edmonton, AB T6G 2B7, Canada Univ Alberta Hosp Edmonton AB Canada T6G 2B7 Edmonton, AB T6G 2B7, Canada Alberta Hosp, Edmonton, AB, Canada Alberta Hosp Edmonton AB CanadaAlberta Hosp, Edmonton, AB, Canada
Titolo Testata:
ACTA PSYCHIATRICA SCANDINAVICA
, volume: 101, anno: 2000, supplemento:, 401
pagine: 3 - 38
SICI:
0001-690X(2000)101:<3:SDISAR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINOR PHYSICAL ANOMALIES; PLASMA HOMOVANILLIC-ACID; AGE-OF-ONSET; NEUROLOGICAL SOFT SIGNS; FIRST-EPISODE SCHIZOPHRENIA; DRUG-INDUCED AKATHISIA; CEREBRAL BLOOD-FLOW; 5-YEAR FOLLOW-UP; INPATIENT FAMILY INTERVENTION; PLANUM TEMPORALE ASYMMETRY;
Keywords:
schizophrenia; sex; gender; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
459
Recensione:
Indirizzi per estratti:
Indirizzo: Chue, P Psychopharmacol Res Unit, 10-126 CSB,8440-112 St, Edmonton, AB T6G2B7, Canada Psychopharmacol Res Unit 10-126 CSB,8440-112 St Edmonton AB Canada T6G 2B7
Citazione:
A. Leung e P. Chue, "Sex differences in schizophrenia, a review of the literature", ACT PSYC SC, 101, 2000, pp. 3-38

Abstract

Objective: To comprehensively and critically review the literature on gender differences in schizophrenia. Method: An initial search of MEDLINE abstracts (1966-1999) was conducted using the terms sex or gender and schizophrenia, followed by systematic search of all relevant articles. Results: Males have consistently an earlier onset, poorer premorbid functioning and different premorbid behavioral predictors. Males show more negative symptoms and cognitive deficits, with greater structural brain and neurophysiological abnormalities. Females display more affective symptoms, auditory hallucinations and persecutory delusions with more rapid and greater responsivity to antipsychotics in the premenopausal period but increased sideeffects. Course of illness is more favorable in females in the short- and middle-term, with less smoking and substance abuse. Families of males are more critical, and expressed emotion has a greater negative impact on males. There are no clear sex differences in family history, obstetric complications, minor physical anomalies and neurological soft signs. Conclusion: This review supports the presence of significant differences between schizophrenic males and females arising from the interplay of sex hormones, neurodevelopmental and psychosocial sex differences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 22:22:11