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Titolo:
Early phase collagen synthesis in lungs of rats exposed to bleomycin
Autore:
Van Hoozen, BE; Grimmer, KL; Marelich, GP; Armstrong, LC; Last, JA;
Indirizzi:
Univ Calif Davis, UC Tox Subst Res & Teaching Program, Dept Internal Med, Div Pulm & Crit Care Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 & Crit Care Med, Davis, CA 95616 USA
Titolo Testata:
TOXICOLOGY
fascicolo: 1, volume: 147, anno: 2000,
pagine: 1 - 13
SICI:
0300-483X(20000519)147:1<1:EPCSIL>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PULMONARY FIBROSIS; III PROCOLLAGEN PEPTIDE; BRONCHOALVEOLAR LAVAGE FLUID; GROWTH-FACTOR-BETA; GENE-EXPRESSION; I PROCOLLAGEN; EXTRACELLULAR-MATRIX; MESSENGER-RNA; QUANTITATION; SERUM;
Keywords:
bleomycin; collagen; pulmonary fibrosis; silica; lung;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Last, JA Univ Calif Davis, UC Tox Subst Res & Teaching Program, Dept Internal Med, Div Pulm & Crit Care Med, Surge 1,Room 1131, Davis, CA 95616 USA Univ Calif Davis Surge 1,Room 1131 Davis CA USA 95616 A 95616 USA
Citazione:
B.E. Van Hoozen et al., "Early phase collagen synthesis in lungs of rats exposed to bleomycin", TOXICOLOGY, 147(1), 2000, pp. 1-13

Abstract

Skin wound healing exhibits type III collagen synthesis occurring transiently as early as 10 h after injury, with subsequent synthesis of type I to form a scar. We hypothesized that similar collagen type switching also occurred in the bleomycin model of lung fibrosis in the rat. We could measure elevated lung collagen synthesis rates as early as 4 days after administration of bleomycin. Collagen type I:III ratios in whole lung remained constant for the first 7 days at the control level of 2:1, then increased to as highas 5:1 at day 21. Procollagen mRNA content, expressed as a ratio of type I:III mRNAs, was consistent with the protein synthesis data and the observedratio of collagen types bring made by the lungs at the various time pointsevaluated. We conclude that a transient increase in type III relative to type I collagen does not occur in the bleomycin rat lung model. Therefore, the sequence of type-specific collagen expression and deposition in the skinwound healing model is not entirely analogous to this widely used animal model of pulmonary fibrosis. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:50:54