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Titolo:
Vitronectin deficiency is associated with increased wound fibrinolysis anddecreased microvascular angiogenesis in mice
Autore:
Jang, YC; Tsou, R; Gibran, NS; Isik, FF;
Indirizzi:
Puget Sound Hlth Care Syst, Dept Surg, Seattle, WA USA Puget Sound Hlth Care Syst Seattle WA USA st, Dept Surg, Seattle, WA USA Univ Washington, Harborview Med Ctr, Seattle, WA 98104 USA Univ Washington Seattle WA USA 98104 rview Med Ctr, Seattle, WA 98104 USA
Titolo Testata:
SURGERY
fascicolo: 6, volume: 127, anno: 2000,
pagine: 696 - 704
SICI:
0039-6060(200006)127:6<696:VDIAWI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR; S-PROTEIN VITRONECTIN; EXTRACELLULAR-MATRIX; CELL-ADHESION; ALPHA(V) INTEGRINS; HUMAN-PLASMA; FIBRONECTIN; RECEPTORS; TYPE-1; CDNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Isik, FF VA Med Ctr, Dept Surg 112, 1660 S Columbian Way, Seattle, WA 98108 USA VA Med Ctr 1660 S Columbian Way Seattle WA USA 98108 WA 98108 USA
Citazione:
Y.C. Jang et al., "Vitronectin deficiency is associated with increased wound fibrinolysis anddecreased microvascular angiogenesis in mice", SURGERY, 127(6), 2000, pp. 696-704

Abstract

Background. Vitronectin has several putative functions including regulating hemostasis, cell adhesion and cell migration. However, the targeted deletion of vitronectin in mice results in normal development and normal coagulation parameters. To determine whether vitronectin may be necessary for nondevelopmental processes, we examined the response to tissue injury in vitronectin-null mice. Methods. We examined wound healing in control and vibronectin-null mice byhealing rate, zymography reverse zymography, and Western blots. Results. We found that dermal wound healing was slightly delayed in mice lacking vitronectin. More importantly, we found extensive areas of delayed hemorrhage near the sprouting tips of microvessels between days 7 and 14, which temporally coincided with increased urokinase-type plasminogen activator and tissue-type plasminogen activator activity by zymography. Though Western blots confirmed the presence of plasminogen activator inhibitor-1 protein throughout wound repair and reverse zymograms showed decreased plasminogen activator inhibitor-1 activity between days 7 and 14. Conclusions, Loss of vitronectin in mice was associated with changes in the fibrinolytic balance, and this may have led to focal sites of delayed hemorrhage. The mechanism that resulted in released angiogenesis and the formation of larger blood vessels in response to tissue injury remains unknown. This study suggests that vitronectin may have several distinct functions that are not require for normal development but are manifested in response totissue injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:25:39