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Titolo:
A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury
Autore:
Yokota, R; Fukai, H; Shimamura, T; Suzuki, T; Watanabe, Y; Nagashima, K; Kishida, A; Furukawa, H; Hayashi, T; Todo, S;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Surg 1, Kita Ku, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Hokkaido Univ, Sch Med, Dept Pathol 2, Kita Ku, Sapporo, Hokkaido 0608638,Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 poro, Hokkaido 0608638,Japan Hokkaido Inst Publ Hlth, Sapporo, Hokkaido, Japan Hokkaido Inst Publ HlthSapporo Hokkaido Japan Sapporo, Hokkaido, Japan
Titolo Testata:
SURGERY
fascicolo: 6, volume: 127, anno: 2000,
pagine: 661 - 669
SICI:
0039-6060(200006)127:6<661:ANHRSN>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; HYPOCHLOROUS ACID; HEPATIC ISCHEMIA; ENDOTHELIAL-CELLS; XANTHINE-OXIDASE; NITRIC-OXIDE; SUPEROXIDE; RAT; TRANSPLANTATION; ATTENUATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Todo, S Hokkaido Univ, Sch Med, Dept Surg 1, Kita Ku, N 15,W 7, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ N 15,W 7 Sapporo Hokkaido Japan 0608638 08638, Japan
Citazione:
R. Yokota et al., "A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury", SURGERY, 127(6), 2000, pp. 661-669

Abstract

Background, Reactive oxygen species have been considered to be involved inliver injury at the procurement, preservation, and transplantation from donors without beating hearts. A novel hydroxyl radical scavenger, nicaraven with hydrophilic and lipophilic properties, infiltrates both intracellular and extracellular spaces where it effectively scavenges reactive oxygen species. Protection by nicaraven against ischemia and reperfusion damage of the brain, heart, and kidneys has been shown. The effect of this agent on theliver remains unclear. Methods. Two-hour total hepatic vascular exclusion was used. Eighteen beagle dogs were randomly assigned to 2 groups: 12 animals were not treated (group I) and 6 were treated with nicaraven (group II). Nicaraven was administered intravenously (2mg/kg/min)for 60 minutes before ischemia and for 3 hours, starting 30 minutes before reperfusion. Results. Two-week survival rates were 25 % in group I and 100% in group II(P <.01). Nicaraven inhibited lipid peroxidation in the liver, improved hepatic and systemic hemodynamics and energy metabolism, and suppressed liverenzyme release, endothelin-1 elevation in hepatic venous blood, histologicdamage, and neutrophil infiltration into the liver. Conclusions. Nicaraven exerted hepatic protection against warm ischemia and reperfusion injury. This may indicate nicaraven as a potential candidate to attenuate liver injury from warm ischemia and preservation in transplantation from donors without beating hearts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 07:34:45