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Titolo:
RAPID CLASSICAL-CONDITIONING OF ODOR RESPONSE IN A PHYSIOLOGICAL MODEL FOR OLFACTORY RESEARCH, THE TIGER SALAMANDER
Autore:
DORRIES KM; WHITE J; KAUER JS;
Indirizzi:
TUFTS UNIV,SCH MED,DEPT NEUROSCI,136 HARRISON AVE BOSTON MA 02111 TUFTS UNIV,SCH MED,DEPT ANAT & CELL BIOL BOSTON MA 02111
Titolo Testata:
Chemical senses
fascicolo: 3, volume: 22, anno: 1997,
pagine: 277 - 286
SICI:
0379-864X(1997)22:3<277:RCOORI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
VOLTAGE-SENSITIVE DYE; MUCOSAL ACTIVITY PATTERNS; MITRAL TUFTED CELLS; RECEPTOR NEURONS; SPATIAL PATTERNS; ISOVALERIC ACID; UNIT RESPONSES; BULB NEURONS; STIMULATION; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
K.M. Dorries et al., "RAPID CLASSICAL-CONDITIONING OF ODOR RESPONSE IN A PHYSIOLOGICAL MODEL FOR OLFACTORY RESEARCH, THE TIGER SALAMANDER", Chemical senses, 22(3), 1997, pp. 277-286

Abstract

In recent years there have been a number of important advances in theunderstanding of cellular mechanisms related to olfactory function. Hypotheses regarding the complex relationships among odorant structure,physiological activity and behavioral outcome generated by these findings, however, remain largely untested due to a paucity of psychophysical data on stimulus discrimination in the same experimental species. Comparisons between behavioral and physiological responses are essential for elucidating the critical aspects of stimulus coding in sensory systems. We have developed a method for generating psychophysical datain one of the primary model species used in olfactory research, the tiger salamander, Ambystoma tigrinum. These psychophysical experiments are carried out under the same conditions as physiological experimentsin our laboratory. Using classical conditioning, individual salamanders are trained over a period of 2-3 h to show skin potential responsesto odor and not air. Failure to train using backward pairing demonstrates that the response is not due to sensitization or pseudoconditioning. The conditioned response is mediated by the olfactory pathway, as it is blocked by olfactory nerve section. We show that salamanders detect three odorants that are commonly used stimuli in physiological experiments (butyl alcohol, butyl acetate and amyl acetate), but cannot detect a fourth common experimental odorant, camphor. This method should be a powerful tool for studying olfactory information processing by providing data on discriminability of stimuli used in salamander physiological studies.

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Documento generato il 29/03/20 alle ore 09:32:15