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Titolo:
Reproducibility of early and late asthmatic responses to allergen challenge in a large group of asthmatics
Autore:
Dente, FL; Bacci, E; Di Franco, A; Giannini, D; Conti, I; Macchioni, P; Scuotri, L; Taccola, M; Vagaggini, B; Paggiaro, PL;
Indirizzi:
Univ Pisa, Cardiothorac Dept, Resp Pathophysiol Unit, Pisa, Italy Univ Pisa Pisa Italy iothorac Dept, Resp Pathophysiol Unit, Pisa, Italy
Titolo Testata:
RESPIRATORY MEDICINE
fascicolo: 5, volume: 94, anno: 2000,
pagine: 441 - 447
SICI:
0954-6111(200005)94:5<441:ROEALA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHIAL RESPONSIVENESS; AIRWAY RESPONSIVENESS; BRONCHOALVEOLAR LAVAGE; INDUCED INCREASE; METHACHOLINE; BRONCHOPROVOCATION; PROVOCATION; HISTAMINE; CHILDREN; TESTS;
Keywords:
reproducibility; allergen early asthmatic response; allergen late asthmatic response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Dente, FL Osped Cisanello, UO Pneumol & Fisiopatol Resp, Via Paradisa 2, I-56100 Pisa, Italy Osped Cisanello Via Paradisa 2 Pisa Italy I-56100 0 Pisa, Italy
Citazione:
F.L. Dente et al., "Reproducibility of early and late asthmatic responses to allergen challenge in a large group of asthmatics", RESP MED, 94(5), 2000, pp. 441-447

Abstract

The specific bronchial provocative test (sBPT) coupled with allergen is used to investigate asthma. Very few studies have examined the reproducibility of responses to allergen challenge. The aim of this study was to measure the reproducibility of PD20FEV1 allergen and late asthmatic response (LAR) in 53 asthmatics and to relate the reproducibility to the time interval between two allergen challenges. Fifty-three atopic asthmatics performed two allergen challenges nor less than 2 and not more than 26 weeks apart. Randomly, 19 subjects were assignedto a short-interval group (14-35 days between the two tests) and 34 to a long-interval group (40-180 days). In each challenge, the PD20FEV1 was sought for and the maximum % fall in FEV1 from 3 to 7 h after the allergen challenge was evaluated as a measurement of magnitude of the LAR. High intraclass correlation coefficients (R-I) were found for both PD20FEV1 (R-I = 0.78) and LAR(R-I = 0.77) in all subjects. PD20FEV1 allergen showed a high R-I in the long-interval group (R-I = 0.80), but a low R-I in the short-interval group (R-I = 0.63). In contrast LAR showed a lower R-I in the long-interval group (R-I = 0.68) than in the short-interval group (R-I = 0.77). Moreover, the R-I for PD10FEV1 was particularly low in subjects witha dual pattern to the allergen challenge and a short interval between the two allergen challenges. Our study confirmed that asthmatic responses induced by allergen challengehave a good reproducibility. Moreover, we have demonstrated that the interval between two allergen challenges can determine a change in reproducibility in asthmatic responses induced by allergen challenge.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 02:58:25