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Titolo:
Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studies
Autore:
Kegeles, LS; Shungu, DC; Anjilvel, S; Chan, S; Ellis, SP; Xanthopoulos, E; Malaspina, D; Gorman, JM; Mann, JJ; Laruelle, M; Kaufmann, CA;
Indirizzi:
Columbia Univ, Dept Psychiat, New York, NY 10027 USA Columbia Univ New York NY USA 10027 Dept Psychiat, New York, NY 10027 USA Columbia Univ, Dept Radiol, New York, NY 10027 USA Columbia Univ New YorkNY USA 10027 , Dept Radiol, New York, NY 10027 USA New York State Psychiat Inst, Brain Imaging Div, Dept Neurosci, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA New York State Psychiat Inst, Brain Imaging Div, Dept Clin Psychobiol, NewYork, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 NewYork, NY 10032 USA
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 3, volume: 98, anno: 2000,
pagine: 163 - 175
SICI:
0925-4927(20000515)98:3<163:HPISMR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE; HUMAN BRAIN; CEREBROSPINAL-FLUID; GLUTAMATERGIC DYSFUNCTION; PREFRONTAL CORTEX; HEALTHY CONTROLS; BASAL GANGLIA; FRONTAL LOBES; HYPOTHESIS; DISORDER;
Keywords:
schizophrenia; hippocampus; magnetic resonance imaging; proton magnetic resonance spectroscopy; neurochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Kegeles, LS Dept Neurosci, 1051 Riverside Dr,Box 42, New York, NY 10032 USA Dept Neurosci 1051 Riverside Dr,Box 42 New York NY USA 10032 A
Citazione:
L.S. Kegeles et al., "Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studies", PSYCH RES-N, 98(3), 2000, pp. 163-175

Abstract

The hippocampus is a site of previously reported structural and functionalabnormalities in schizophrenia. We used magnetic resonance imaging(MRI) and proton magnetic resonance spectroscopy (MRS) to measure gray matter volumes, the neuronal marker N-acetylaspartate (NAA), and the combination of glutamate (Glu), glutamine (Gln), and gamma-aminobutyric acid (GABA), designated Glx. Measurements were obtained of the medial temporal lobe, centered onthe hippocampus, in 10 male patients with schizophrenia (3 neuroleptic-medicated and 7 medication-free), and 10 matched normal volunteers. MRI volumetric measurements and MRS data obtained with short echo time (TE = 20 ms) one-dimensional STEAM chemical shift imaging (CSI) on a GE 1.5 Tesla Signa system were analyzed. A laterality index [(L-R)/(L + R)] was generated from the ratio of Glx to choline-containing compounds (Cho) to test asymmetry changes. Reliability of the MRS measures was assessed with five test-retest studies of healthy volunteers and showed coefficients of variation (CV) in the range of 36-44% for the MRS ratios and standard deviations (S.D.) of 0.15-0.17 for the laterality indices. The Glx/Cho laterality index showed a relative right-sided excess in this region in the patients (-0.23 +/- 0.20) compared to the controls (+0.06+/-0.20), which was not confounded by tissue composition or placement variability of the MRS voxels. Hippocampal volume deficit and asymmetry were not significant, and other MRS measures showed no differences between patients and controls. The preliminary finding of a lateralized abnormality in Clx is consistent with postmortem findings of asymmetric neurochemical temporal lobe abnormalities in schizophrenia. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:06:25