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Titolo:
Acetogenic isoquinoline alkaloids part 136 - 8-O-methyldioncophyllinol B and revised structures of other 7,6 '-coupled naphthylisoquinoline alkaloidsfrom Triphyophyllum peltatum (Dioncophyllaceae)
Autore:
Bringmann, G; Gunther, C; Saeb, W; Mies, J; Brun, R; Assi, LA;
Indirizzi:
Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97074 n Chem, D-97074 Wurzburg, Germany Schweizer Tropeninst, CH-4002 Basel, Switzerland Schweizer Tropeninst Basel Switzerland CH-4002 H-4002 Basel, Switzerland Univ Abidjan, Ctr Natl Florist, Abidjan 08, Cote Ivoire Univ Abidjan Abidjan Cote Ivoire 08 atl Florist, Abidjan 08, Cote Ivoire
Titolo Testata:
PHYTOCHEMISTRY
fascicolo: 3, volume: 54, anno: 2000,
pagine: 337 - 346
SICI:
0031-9422(200006)54:3<337:AIAP1->2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO; ABSOLUTE-CONFIGURATION; PLASMODIUM-FALCIPARUM; DEGRADATION PROCEDURE; ASSAY;
Keywords:
Triphyophyllum peltatum; Dioncophyllaceae; structural elucidation; naphthylisoquinoline alkaloids; 8-O-methyldioncophyllinol B; dioncophyllinol B; 1-epi-dioncophylline B; 8-O-methyl-1-epi-dioncophylline B; dioncophyllinol D; dioncophylline D; 8-O-methyldioncophylline D; antimalarial activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Bringmann, G Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97074 74 Wurzburg, Germany
Citazione:
G. Bringmann et al., "Acetogenic isoquinoline alkaloids part 136 - 8-O-methyldioncophyllinol B and revised structures of other 7,6 '-coupled naphthylisoquinoline alkaloidsfrom Triphyophyllum peltatum (Dioncophyllaceae)", PHYTOCHEM, 54(3), 2000, pp. 337-346

Abstract

The isolation and structural elucidation of a new naphthylisoquinoline alkaloid, 8-O-methyldioncophyllinol B, from Triphyophyllum peltatum (Hutch. etDalz. ) Airy Shaw (Dioncophyllaceae) is described, together with the revised structures of other 'B-type' compounds previously misidentified as dioncophylline D, dioncophyllinol D, and 8-O-methyldioncophylline D. All of the presently described structures are 7,6'-coupled and thus have to be addressed as 'B-type' naphthylisoquinoline alkaloids. This is in contrast to the initially defined 'D-type' structures, which are 7,8'-coupled as confirmed bya total synthesis of dioncophylline D. Some of these natural and syntheticnaphthylisoquinolines were found to display good in vitro antiplasmodial activities. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 01:10:40