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Titolo:
Inactivation of alpha 7 ACh receptors and activation of non-alpha 7 ACh receptors both contribute to long term potentiation induction in the hippocampal CA1 region
Autore:
Fujii, S; Ji, ZX; Sumikawa, K;
Indirizzi:
Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA Univ CalifIrvine Irvine CA USA 92697 obiol & Behav, Irvine, CA 92697 USA Yamagata Univ, Sch Med, Dept Physiol, Yamagata 9909585, Japan Yamagata Univ Yamagata Japan 9909585 pt Physiol, Yamagata 9909585, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 286, anno: 2000,
pagine: 134 - 138
SICI:
0304-3940(20000602)286:2<134:IOA7AR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NICOTINIC ACETYLCHOLINE-RECEPTORS; COGNITIVE FUNCTION; RAT HIPPOCAMPUS; INTERNEURONS; SLICES; INVOLVEMENT; SUBTYPES; RELEASE; MEMORY;
Keywords:
nicotinic acetylcholine receptor; nicotine; metyllycaconitine; dihydro-beta-erythroidine; A85380; long-term potentiation; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Sumikawa, K Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 v, Irvine, CA 92697 USA
Citazione:
S. Fujii et al., "Inactivation of alpha 7 ACh receptors and activation of non-alpha 7 ACh receptors both contribute to long term potentiation induction in the hippocampal CA1 region", NEUROSCI L, 286(2), 2000, pp. 134-138

Abstract

Acute and chronic nicotine exposure differentially facilitate the induction of long-term potentiation (LTP), a synaptic model of learning and memory,in the hippocampal CA1 region. The mechanisms underlying these effects of nicotine, however, are unknown. In the present study, both nicotinic acetylcholine receptor (nAChR) agonists and an alpha 7 nAChR antagonist facilitated the induction LTP in the hippocampal CA1 region of naive rat. Furthermore, chronic nicotine treatment lowered the threshold for induction of LTP, and acute application of nicotinic agonists, but not an alpha 7 antagonist, further facilitated LTP induction in the chronic-nicotine-treated hippocampus. These results suggest not only that both activation of non-alpha 7 nAChRs and inactivation of alpha 7 nAChRs contribute to LTP induction, but alsothat chronic-nicotine-mediated facilitation of LTP induction is due to chronic-nicotine-induced desensitization of alpha 7 nAChRs, (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/08/20 alle ore 17:53:33