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Titolo:
The role of tachykinin NK-1 receptors in the area postrema of ferrets in emesis
Autore:
Ariumi, H; Saito, R; Nago, S; Hyakusoku, M; Takano, Y; Kamiya, H;
Indirizzi:
Fukuoka Univ, Fac Pharmaceut Sci, Dept Pharmacol, Fukuoka 8140180, Japan Fukuoka Univ Fukuoka Japan 8140180 ept Pharmacol, Fukuoka 8140180, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 286, anno: 2000,
pagine: 123 - 126
SICI:
0304-3940(20000602)286:2<123:TROTNR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANCE-P; EMETIC REFLEX; NK1 RECEPTOR; C-FOS; RAT; ANTAGONISTS; CAT; IMMUNOREACTIVITY; ENKEPHALIN; EXPRESSION;
Keywords:
emesis; area postrema; NK-1 antagonists; ferret; nucleus tractus solitarius;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Saito, R Fukuoka Univ, Fac Pharmaceut Sci, Dept Pharmacol, Fukuoka 8140180, Japan Fukuoka Univ Fukuoka Japan 8140180 acol, Fukuoka 8140180, Japan
Citazione:
H. Ariumi et al., "The role of tachykinin NK-1 receptors in the area postrema of ferrets in emesis", NEUROSCI L, 286(2), 2000, pp. 123-126

Abstract

The role of tachykinin NK-1 receptors in the area postrema (AP) in emesis was examined in ferrets. Strong c-fos-like immunoreactivity was observed inthe AP and nucleus tractus solitalius (NTS) in cisplatin (10 mg/kg, i.p.)-treated animals, but not in control animals. The number of the central emetogen morphine-induced vomits and retches was remarkably reduced (95%) and that of the peripheral emetogen copper sulphate-induced vomits was significantly (54%) reduced by AP lesion. Pretreatment with the tachykinin NK-1 receptor antagonists HSP-117 (1.0 mu g) and CP-99,984 (7.5 mu g) into the AP decreased the numbers of Vomits and retches induced by morphine and copper sulphate. These results suggest that NK-1 receptors in the AP are involved inthe mechanism of emesis induced by morphine and copper sulphate. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:45:07