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Titolo:
Sex-related hormonal influences on pain and analgesic responses
Autore:
Fillingim, RB; Ness, TJ;
Indirizzi:
Univ Alabama, Dept Psychol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 pt Psychol, Birmingham, AL 35294 USA Univ Alabama, Dept Anesthesiol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 nesthesiol, Birmingham, AL 35294 USA
Titolo Testata:
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
fascicolo: 4, volume: 24, anno: 2000,
pagine: 485 - 501
SICI:
0149-7634(200006)24:4<485:SHIOPA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREGNANCY-INDUCED ANALGESIA; STRESS-INDUCED ANALGESIA; RAT ESTROUS-CYCLE; MORPHINE-INDUCED ANTINOCICEPTION; OPIATE RECEPTOR MECHANISMS; NON-DYSMENORRHEIC WOMEN; SPINAL-CORD DYNORPHIN; NERVE LIGATION PSNL; MENSTRUAL-CYCLE; FEMALE RATS;
Keywords:
female; menstrual cycle; nociceptive transmission; pain threshold; analgesia; sex steroids; estrogen;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
176
Recensione:
Indirizzi per estratti:
Indirizzo: Fillingim, RB Univ Alabama, Dept Psychol, 1300 Univ Blvd, Birmingham, AL 35294 USA Univ Alabama 1300 Univ Blvd Birmingham AL USA 35294 5294 USA
Citazione:
R.B. Fillingim e T.J. Ness, "Sex-related hormonal influences on pain and analgesic responses", NEUROSCI B, 24(4), 2000, pp. 485-501

Abstract

Considerable evidence indicates sex-related differences in pain responses and in the effectiveness of various analgesic agents. Specifically, femalesare at greater risk for experiencing many forms of clinical pain and are more sensitive to experimentally induced pain relative to males. Regarding analgesic responses, nonhuman animal studies indicate greater opioid analgesia for males, while a limited human literature suggests the opposite. Though the mechanisms underlying these effects remain unclear, the influence of gonadal hormones on nociceptive processing represents one plausible pathwaywhereby such sex differences could emerge. The present article reviews thecomplex literature concerning sex steroid effects on pain responses and analgesia. First, nonhuman animal research related to hormonal effects on nociceptive sensitivity and analgesic responses is presented. Next, human studies regarding gonadal hormonal influences on experimental pain responses are reviewed. Several potential mechanisms underlying hormonal effects on nociceptive processing are discussed, including hormonal effects to both peripheral and central nervous system pathways involved in pain transmission. Finally, based on these findings we draw several conclusions and make specific recommendations that will guide future research as it attempts to elucidate the magnitude and importance of sex-related hormonal effects on the experience of pain. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 21:33:17