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Titolo:
The effects of ibotenic acid lesions of the medial and lateral prefrontal cortex on latent inhibition, prepulse inhibition and amphetamine-induced hyperlocomotion
Autore:
Lacroix, L; Spinelli, S; White, W; Feldon, J;
Indirizzi:
Swiss Fed Inst Technol, Behav Neurobiol Lab, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 97, anno: 2000,
pagine: 459 - 468
SICI:
0306-4522(2000)97:3<459:TEOIAL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE RESPONSE; NEUROLEPTIC-NAIVE PATIENTS; STRESS-INDUCED INCREASE; VENTRAL TEGMENTAL AREA; RAT CEREBRAL-CORTEX; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; CORTICAL DOPAMINE; CHRONIC-SCHIZOPHRENIA; ELECTRICAL-STIMULATION;
Keywords:
latent inhibition; prepulse inhibition; medial prefrontal cortex; lateral prefrontal cortex; schizophrenia; lesion;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
103
Recensione:
Indirizzi per estratti:
Indirizzo: Feldon, J Swiss Fed Inst Technol, Behav Neurobiol Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schorenstr 16 Schwerzenbach Switzerland CH-8603
Citazione:
L. Lacroix et al., "The effects of ibotenic acid lesions of the medial and lateral prefrontal cortex on latent inhibition, prepulse inhibition and amphetamine-induced hyperlocomotion", NEUROSCIENC, 97(3), 2000, pp. 459-468

Abstract

Hypofunction of prefrontal cortical regions, such as dorsolateral and orbital regions, has been suggested to contribute to the symptomatology of schizophrenia. In the rat, the medial and the lateral prefrontal cortices are considered as homologs of the primate dorsolateral and orbital prefrontal cortices, respectively. The present study investigated in rats the effects oflesions of the medial and lateral prefrontal cortices on latent inhibition, prepulse inhibition and amphetamine-induced activity. These paradigms areknown to be modulated by the mesolimbic dopaminergic system, a system thathas been suggested to be involved in the symptomatology of schizophrenia. Latent inhibition and prepulse inhibition are disrupted in schizophrenic patients as well as in rats treated with amphetamine. Amphetamine-induced activity was tested under dim light (low stress) and bright light (high stress) because stressful situations selectively increase mesocortical dopamine activity. Lateral prefrontal cortex lesioned animals did not differ in theirbehavior from control animals in any of the paradigms used in this study. Medial prefrontal cortex lesions did not affect latent inhibition but increased prepulse inhibition. In the amphetamine-induced activity experiment, prior to drug administration, open field locomotion was reduced under brightillumination for all lesion groups. After amphetamine administration, medial prefrontal cortex lesions attenuated the hyperlocomotor effect of the drug under the dim light condition and potentiated it under the bright light condition. The results indicate that medial and lateral prefrontal cortex can be functionally differentiated by their involvement in the modulation ofbehavior requiring mesocorticolimbic dopamine activation. The results in amphetamine induced activity suggest that the behavioral outcomes associated with medial prefrontal cortex depend on the background (stress) against which the evaluation is made. The results also support the notion that prepulse inhibition may be a better model than latent inhibitionof the symptoms of schizophrenia associated with dysfunctional prefrontal activity. (C) 2000 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 26/01/20 alle ore 01:19:31