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Titolo:
GDNF but not BDNF is increased in cerebrospinal fluid in amyotrophic lateral sclerosis
Autore:
Grundstrom, E; Lindholm, D; Johansson, A; Blennow, K; Askmark, H;
Indirizzi:
Univ Uppsala Hosp, Dept Neurosci Neurol, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 Neurol, S-75185 Uppsala, Sweden Univ Uppsala, Ctr Biomed, Dept Neurosci Neurobiol, S-75123 Uppsala, SwedenUniv Uppsala Uppsala Sweden S-75123 i Neurobiol, S-75123 Uppsala, Sweden Sahlgrens Univ Hosp, Dept Clin Neurosci, S-43180 Molndal, Sweden SahlgrensUniv Hosp Molndal Sweden S-43180 osci, S-43180 Molndal, Sweden
Titolo Testata:
NEUROREPORT
fascicolo: 8, volume: 11, anno: 2000,
pagine: 1781 - 1783
SICI:
0959-4965(20000605)11:8<1781:GBNBII>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL MOTOR-NEURONS; NEUROTROPHIC FACTOR; SURVIVAL FACTOR; MOTONEURONS; MUSCLE; EXPRESSION; BRAIN; ASTROCYTES;
Keywords:
amyotrophic lateral sclerosis (ALS); brain-derived neurotrophic factor (BDNF); cerebrospinal fluid (CSF); ELISA; glial cell line-derived neurotrophic factor (GDNF);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Grundstrom, E Univ Uppsala Hosp, Dept Neurosci Neurol, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 5 Uppsala, Sweden
Citazione:
E. Grundstrom et al., "GDNF but not BDNF is increased in cerebrospinal fluid in amyotrophic lateral sclerosis", NEUROREPORT, 11(8), 2000, pp. 1781-1783

Abstract

Cerebrospinal fluid from 15 patients with ALS and 11 controls without neurological disease were analysed for levels of the neurotrophic factors BDNF and GDNF. Analyses were performed using a sensitive sandwich immunoassay (ELISA). There was no significant difference in BDNF levels between the ALS patients and the control subjects studied. Measurable revels of GDNF were found in 12 out of 15 ALS samples. GDNF was not detected in CSF from any of the control subjects. The finding of increased CSF levels of GDNF in ALS compared to controls, together with earlier findings of increased expression of GDNF mRNA in muscle in ALS, indicates that the capacity to synthesize GDNF is enhanced in this disorder. NeuroReport 11:1781-1783 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:27:03