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Titolo:
A comparison of endothelial function in Caucasian and Chinese women beforeand after the menopause
Autore:
McCrohon, JA; Woo, KS; Celermajer, DS;
Indirizzi:
Royal Prince Alfred Hosp, Dept Cardiol, Sydney, NSW 2050, Australia Royal Prince Alfred Hosp Sydney NSW Australia 2050 y, NSW 2050, Australia Chinese Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China Chinese Univ Hong Kong Hong Kong Hong Kong Peoples R China oples R China Univ Sydney, Dept Med, Sydney, NSW 2006, Australia Univ Sydney Sydney NSWAustralia 2006 pt Med, Sydney, NSW 2006, Australia
Titolo Testata:
MATURITAS
fascicolo: 1, volume: 35, anno: 2000,
pagine: 31 - 37
SICI:
0378-5122(20000428)35:1<31:ACOEFI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE REPLACEMENT THERAPY; DENSITY LIPOPROTEIN CHOLESTEROL; POSTMENOPAUSAL WOMEN; SEX-HORMONES; ADULTS; ATHEROSCLEROSIS; DYSFUNCTION; ESTROGEN; VASODILATION; DISEASE;
Keywords:
endothelial function; menopause; Chinese; Caucasian;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Celermajer, DS Royal Prince Alfred Hosp, Dept Cardiol, Missenden Rd, Sydney, NSW 2050, Australia Royal Prince Alfred Hosp Missenden Rd Sydney NSW Australia 2050
Citazione:
J.A. McCrohon et al., "A comparison of endothelial function in Caucasian and Chinese women beforeand after the menopause", MATURITAS, 35(1), 2000, pp. 31-37

Abstract

Objective: Arterial endothelial dysfunction is a key atherogenic event that may be related to oestrogen status. We therefore aimed to compare menopause-related changes in endothelial physiology in Chinese and Caucasian females. Methods: We studied 40 female subjects; 20 Chinese from a rural region of Southern China (ten premenopausal, aged 20-35 years, and ten postmenopausal, aged 55-66 years), and 20 age-matched Caucasian Females from Sydney, Australia. All women had a clinical history, resting blood pressure and fasting lipids measured, and endothelial function assessed. Using high-resolution external vascular ultrasound, brachial artery diameter was measured at rest, after flow increase (causing endothelium-dependent dilatation) and after sublingual glyceryl trinitrate (GTW) (an endothelium-independent dilator). Results: There was a significant decline in endothelium-dependent dilatation (EDD) comparing Caucasian females from the premenopausal versus postmenopausal groups (8.4 +/- 2.7% versus 2.7 +/- 2.9%; P < 0.001). In contrast,there was no significant difference in EDD between pre- and postmenopausalChinese (9.8 +/- 3.3% versus 8.3 +/- 1.7%; P = 0.22). On multivariate analysis, postmenopausal status was associated with impaired EDD in Caucasian females (P < 0.002) independent of serum cholesterol, blood pressure and vessel size. In contrast, EDD in the Chinese females was not significantly influenced by any of these factors. GTW-induced dilatation was also impaired in the older Caucasian females, a finding explained on multivariate analysisby the increased vessel size in this patient group (P = 0.03). Conclusion:Menopause is associated with impaired arterial endothelial function in Caucasian but not Chinese women. This suggests possible ethnic differences in menopause-related vascular changes. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:03:35