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Titolo:
The family history of patients with primary or secondary antiphospholipid syndrome (APS)
Autore:
Weber, M; Hayem, G; DeBandt, M; Palazzo, E; Roux, S; Kahn, MF; Meyer, O;
Indirizzi:
Univ Lyon 1, Bichat Hosp, Dept Rheumatol, Paris, France Univ Lyon 1 Paris France 1, Bichat Hosp, Dept Rheumatol, Paris, France
Titolo Testata:
LUPUS
fascicolo: 4, volume: 9, anno: 2000,
pagine: 258 - 263
SICI:
0961-2033(2000)9:4<258:TFHOPW>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; HLA-DR ANTIGENS; MAJOR HISTOCOMPATIBILITY COMPLEX; ANTICARDIOLIPIN ANTIBODIES; RISK-FACTORS; ANTICOAGULANT; ASSOCIATIONS; MHC; MULTICENTER; DEFICIENCY;
Keywords:
family history; antiphospholipid syndrome; systemic lupus erythematosus; anticardiolipin antibodies; lupus anticoagulant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Weber, M Stadt Triemli Zurich, Klin Rheumatol & Rehabil, CH-8063 Zurich, Switzerland Stadt Triemli Zurich Zurich Switzerland CH-8063 ch, Switzerland
Citazione:
M. Weber et al., "The family history of patients with primary or secondary antiphospholipid syndrome (APS)", LUPUS, 9(4), 2000, pp. 258-263

Abstract

Objective: To evaluate familial history for evidence of antiphospholipid syndrome (APS) and autoimmune disease in rheumatology department patients with primary or secondary APS. Methods: We retrospectively studied patients with APS and systemic lupus erythematosus (SLE) managed at the Rheumatology Department of the Bichat University Hospital, Paris, between 1987 and 1996. Data were collected by chart review and by a 1997 standardized telephone interview. Results: We identified 108 patients with APS managed during the ten-year study period. According to classical classification criteria, 39 patients had primary antiphospholipid syndrome (PAPS) and 69 secondary antiphospholipid syndrome (SAPS). Family history data were obtained for 29 (74%) and 55 (80%) PAPS and SAPS patients, respectively (78% of the 108 patients). Twelve PAPS (41%) and 19 SAPS (35%) patients had one or more relatives with evidence of at least one clinical feature of APS such as thrombosis or recurrent fetal loss; of these patients, seven in the PAPS (24%) and 11 in the SAPS (20%) group had two or more relatives with evidence of a clinical feature ofAPS. Three PAPS (10%) and 14 SAPS (25%) patients had one or more family members with an autoimmune disease. Conclusion: A positive family history for autoimmune disease and/or antiphospholipid syndrome is common in patients with PAPS or SAPS. This finding supports a genetic contribution to APS. The percentage of a positive family history for autoimmune disease tend to be higher in patients with SAPS thanin those with PAPS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:48:37