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Titolo:
The role of RAR and RXR activation in retinoid-induced tissue factor suppression
Autore:
Tenno, T; Botling, J; Oberg, F; Jossan, S; Nilsson, K; Siegbahn, A;
Indirizzi:
Univ Uppsala, Dept Med Sci, S-75185 Uppsala, Sweden Univ Uppsala UppsalaSweden S-75185 ept Med Sci, S-75185 Uppsala, Sweden Univ Uppsala, Dept Genet & Pathol, S-75185 Uppsala, Sweden Univ Uppsala Uppsala Sweden S-75185 et & Pathol, S-75185 Uppsala, Sweden
Titolo Testata:
LEUKEMIA
fascicolo: 6, volume: 14, anno: 2000,
pagine: 1105 - 1111
SICI:
0887-6924(200006)14:6<1105:TRORAR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE PROMYELOCYTIC LEUKEMIA; DISSEMINATED INTRAVASCULAR COAGULATION; CELL-LINE U-937; ACID RECEPTOR; X-RECEPTOR; FACTOR EXPRESSION; NB4 CELLS; DIFFERENTIATION; ALPHA; PROCOAGULANT;
Keywords:
tissue factor; RAR; RXR; differentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Siegbahn, A Univ Uppsala, Dept Med Sci, S-75185 Uppsala, Sweden Univ Uppsala Uppsala Sweden S-75185 S-75185 Uppsala, Sweden
Citazione:
T. Tenno et al., "The role of RAR and RXR activation in retinoid-induced tissue factor suppression", LEUKEMIA, 14(6), 2000, pp. 1105-1111

Abstract

Excessive expression of tissue factor (TF) is a common finding in leukaemic cells and may contribute to thrombotic complications in patients. Retinoic acid has been shown to induce differentiation and reduce TF expression inacute promyelocytic leukaemia (APL) cells in vitro, and to induce remission in APL patients. Treatment of the APL cell line N84 with the specific retinoic acid receptor-alpha (RAR alpha) agonists Ro40-6055 or TTNPB resulted in down-regulation of TF expression and in induction of differentiation. The activation of RAR beta, RAR gamma or retinoid chi receptor (RXR) did not suppress the constitutive TF expression in N84 cells. Moreover, the RAR alpha antagonist Ro41-5253 blocked the retinoid-induced down-regulation of TF. In contrast, in the monoblastic U-937 cell line only a partial suppressionof TF antigen expression and activity was observed by treatment with the RAR agonist TTNPB or the RXR agonist SR11237 alone. However, the combinationof TTNPB and SR11237 resulted in a pronounced down-regulation of TF expression and induction of differentiation in U-937 cells. We show for the firsttime that the activation of both subunits of the RAR alpha-RXR transcriptional complex is needed for TF suppression in U-939 cells, whereas in NB4 cells RAR alpha activation alone is sufficient. Thus, distinct molecular mechanisms for TF suppression seem to be operating In leukaemic cell lines of different origin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:31:31