Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Nimesulide: Some pharmaceutical and pharmacological aspects - An update
Autore:
Singla, AK; Chawla, M; Singh, A;
Indirizzi:
Panjab Univ, Univ Inst Pharmaceut Sci, Div Pharmaceut, Chandigarh 160014, India Panjab Univ Chandigarh India 160014 Pharmaceut, Chandigarh 160014, India Panacea Biotec Ltd, Lalru 140501, Punjab, India Panacea Biotec Ltd Lalru Punjab India 140501 Lalru 140501, Punjab, India
Titolo Testata:
JOURNAL OF PHARMACY AND PHARMACOLOGY
fascicolo: 5, volume: 52, anno: 2000,
pagine: 467 - 486
SICI:
0022-3573(200005)52:5<467:NSPAPA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PERFORMANCE LIQUID-CHROMATOGRAPHY; PROSTAGLANDIN G/H SYNTHASE-1; ALZHEIMERS-DISEASE; CYCLOOXYGENASE-2 INHIBITOR; HUMAN-PLASMA; ALPHA-1-PROTEINASE INHIBITOR; THERAPEUTIC EFFICACY; COLON CARCINOGENESIS; HEALTHY-VOLUNTEERS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
148
Recensione:
Indirizzi per estratti:
Indirizzo: Singla, AK Panjab Univ, Univ Inst Pharmaceut Sci, Div Pharmaceut, Chandigarh 160014, India Panjab Univ Chandigarh India 160014 Chandigarh 160014, India
Citazione:
A.K. Singla et al., "Nimesulide: Some pharmaceutical and pharmacological aspects - An update", J PHARM PHA, 52(5), 2000, pp. 467-486

Abstract

Nimesulide, a non-steroidal anti-inflammatory drug (NSAID), is administered orally or rectally twice daily for a variety of inflammation and pain states. This is a unique NSAID, not only because of its chemical structure butalso because of its specific affinity to inhibit cyclooxygenase-2 (COX-2),thus exerting milder effects on the gastrointestinal mucosa. Current data on selective COX-2 inhibitors suggest that they may have an efficacy similar to that of standard NSAIDs. Initial general clinical experience with selective COX-2 inhibitors appears to show that they are particularly promisingin individuals at risk because of renal diseases, hypertension or congestive heart failure. Various experimental models and clinical studies have demonstrated the anti-inflammatory efficacy of nimesulide. Nimesulide is superior, or at least comparable in efficacy, to other NSAIDs, but is better tolerated and has less potential for adverse reactions. Thus, selective COX-2 inhibitors shouldhave anti-inflammatory effects devoid of side effects on the kidney and stomach. They may also demonstrate new important therapeutic benefits as anticancer agents as well as help prevention of premature labour and even retard the progression of Alzheimer's disease. No clinically significant drug interactions have been reported for nimesulide. Not much has been reported about the pharmaceutical aspects of nimesulide. Its poor aqueous solubility poses bioavailability problems in-vivo. This could be overcome by the formation of inclusion complexes with beta-cyclodextrin, as has been reported by various researchers. However, absence of any in-vivo data regarding the relative absorption of nimesulide from beta-cyclodextrin complex compared with that from conventional formulations of the drug makes the use of such fast-releasing complexes rather questionable. Only a limited number of assay procedures (HPLC, spectrophotometric, spectrofluorimetric) for the determination of nimesulide and its metabolite in plasma/urine samples or in dosage forms have been reported in the literature. The purpose of this review is to provide a concise overview of the pharmacological and pharmaceutical profile of nimesulide. Various investigations carried out recently are reported, although older references to research performed on nimesulide have also been included, where appropriate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:37:52