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Titolo:
Synthesis and anti-aggregatory activity of linear retro-inverso RGD peptides
Autore:
Dal Pozzo, A; Fagnoni, N; Bergonzi, R; Vanini, L; de Castiglione, R; Aglio, C; Colli, S;
Indirizzi:
Ist Ric Chim & Biochim G Ronzoni, I-20133 Milan, Italy Ist Ric Chim & Biochim G Ronzoni Milan Italy I-20133 -20133 Milan, Italy Univ Milan, Inst Pharmacol Sci, E Grossi Paoletti Ctr, Milan, Italy Univ Milan Milan Italy armacol Sci, E Grossi Paoletti Ctr, Milan, Italy
Titolo Testata:
JOURNAL OF PEPTIDE RESEARCH
fascicolo: 6, volume: 55, anno: 2000,
pagine: 447 - 454
SICI:
1397-002X(200006)55:6<447:SAAAOL>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
IIB-IIIA RECEPTOR; ASP-PHE SEQUENCE; PLATELET-AGGREGATION; FIBRINOGEN RECEPTOR; BINDING INTERACTION; POTENT INHIBITORS; ANTAGONISTS; NONPEPTIDE; GPIIB/IIIA; PROPOSAL;
Keywords:
malonyl-aspartic acid; retro-inverso peptides; RGD analogues;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Dal Pozzo, A Ist Ric Chim & Biochim G Ronzoni, Via G Colombo 81, I-20133 Milan, Italy Ist Ric Chim & Biochim G Ronzoni Via G Colombo 81 Milan Italy I-20133
Citazione:
A. Dal Pozzo et al., "Synthesis and anti-aggregatory activity of linear retro-inverso RGD peptides", J PEPT RES, 55(6), 2000, pp. 447-454

Abstract

Six retro-inverso tri- and tetrapeptide analogues of RGD were prepared andtheir anti-aggregatory activity was determined by platelet aggregation tests in comparison with the corresponding parent peptides. An efficient method for the introduction of a malonyl-aspartic residue into a peptide chain is described for the first time. A 2-3-fold decrease in potency or total loss of bioactivity was observed with the new peptides; structure-activity relationships are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:37:18