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Titolo:
c-Fos expression in GABAergic, serotonergic, and other neurons of the pontomedullary reticular formation and raphe after paradoxical sleep deprivation and recovery
Autore:
Maloney, KJ; Mainville, L; Jones, BE;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 surg, Montreal, PQ H3A 2B4, Canada
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 12, volume: 20, anno: 2000,
pagine: 4669 - 4679
SICI:
0270-6474(20000615)20:12<4669:CEIGSA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
EYE-MOVEMENT SLEEP; HIPPOCAMPAL THETA-RHYTHM; CHOLINERGIC CELL AREA; EARLY GENE-EXPRESSION; INDUCED ACTIVE SLEEP; FREELY MOVING CATS; BRAIN-STEM; REM-SLEEP; PONTOMESENCEPHALIC TEGMENTUM; SPINAL MOTONEURONS;
Keywords:
paradoxical sleep; REM sleep; c-Fos expression; reticular formation; raphe; GABAergic; serotonergic; sleep-wake states; muscle atonia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, BE McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, 3801Univ St, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Univ St Montreal PQCanada H3A 2B4 2B4, Canada
Citazione:
K.J. Maloney et al., "c-Fos expression in GABAergic, serotonergic, and other neurons of the pontomedullary reticular formation and raphe after paradoxical sleep deprivation and recovery", J NEUROSC, 20(12), 2000, pp. 4669-4679

Abstract

The brainstem contains the neural systems that are necessary for the generation of the state of paradoxical sleep (PS) and accompanying muscle atonia. Important for its initiation are the pontomesencephalic cholinergic neurons that project into the pontomedullary reticular formation and that we have recently shown increase c-Fos expression as a reflection of neural activity in association with PS rebound after deprivation in rats (Maloney et al., 1999). As a continuation, we examined in the present study c-Fos expression in the pontomedullary reticular and raphe neurons, including importantlyGABAergic neurons [immunostained for glutamic acid decarboxylase (GAD)] and serotonergic neurons [immunostained for serotonin (Ser)]. Numbers of single-labeled c-Fos+ neurons were significantly increased withPS rebound only in the pars oralis of the pontine reticular nuclei (PnO), where numbers of GAD+/c-Fos+ neurons were conversely significantly decreased. c-Fos+ neurons were positively correlated with PS, whereas GAD+/c-Fos+ neurons were negatively correlated with PS, suggesting that disinhibition ofreticular neurons in the PnO from locally projecting GABAergic neurons maybe important in the generation of PS. In contrast, through the caudal ponsand medulla, GAD+/c-Fos+ cells were increased with PS rebound, covaried positively with PS and negatively with the electromyogram (EMG). In the raphepallidus-obscurus, Ser+/c-Fos+ neurons were positively correlated, in a reciprocal manner to GAD+/c-Fos+ cells, with EMG, suggesting that disfacilitation by removal of a serotonergic influence and inhibition by imposition ofa GABAergic influence within the lower brainstem and spinal cord may be important in the development of muscle atonia accompanying PS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 23:37:02