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Titolo:
Neural connections of hypothalamic neuroendocrine nuclei in the rat
Autore:
Saeb-Parsy, K; Lombardelli, S; Khan, FZ; McDowall, K; Au-Yong, ITH; Dyball, REJ;
Indirizzi:
Univ Cambridge, Dept Anat, Cambridge CB2 3DY, England Univ Cambridge Cambridge England CB2 3DY nat, Cambridge CB2 3DY, England
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 7, volume: 12, anno: 2000,
pagine: 635 - 648
SICI:
0953-8194(200007)12:7<635:NCOHNN>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE SECRETION; FEMALE ALBINO-RAT; LIGHT-DARK CYCLE; SUPRACHIASMATIC NUCLEUS; SUPRAOPTIC NUCLEUS; ELECTROPHYSIOLOGICAL EVIDENCE; RETINOHYPOTHALAMIC TRACT; PARAVENTRICULAR NUCLEUS; EFFERENT PROJECTIONS; PERINUCLEAR ZONE;
Keywords:
neural connections; suprachiasmatic nucleus; arcuate nucleus; supraoptic nucleus; paraventricular nucleus; optic nerve;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Saeb-Parsy, K Univ Cambridge, Dept Anat, Downing St, Cambridge CB2 3DY, England Univ Cambridge Downing St Cambridge England CB2 3DY England
Citazione:
K. Saeb-Parsy et al., "Neural connections of hypothalamic neuroendocrine nuclei in the rat", J NEUROENDO, 12(7), 2000, pp. 635-648

Abstract

The secretion of many hormones, including oxytocin, vasopressin and growthhormone, is not constant but shows a day-night rhythm. The suprachiasmaticnucleus (SCN) is thought to generate most mammalian biological rhythms andprevious studies have reported suprachiasmatic efferents to the paraventricular nucleus (PVN) and the supraoptic nucleus (SON). We used in vivo extracellular electrophysiological techniques to show that the SCN also sends direct and indirect neural projections to the arcuate nucleus (ARC). This projection consisted of both excitatory and inhibitory components and may contribute to the entrainment of the rhythm in growth hormone secretion to the day-night cycle. Some SCN neurones appear to project to both the SON and the ARC. The SCN in turn receives excitatory and inhibitory inputs from the ARC and the peri-nuclear zone of the SON (peri-SON), which may provide feedback information, as well as allowing nonphotic entrainment of the SCN, for example, in response to feeding. Our data thus suggest extensive two-way connections between the SCN and its target nuclei which may contribute to thegeneration of day-night neuroendocrine rhythms. They also suggest the existence of indirect retinal projections to the ARC and PVN. We further investigated the retinal projection to the SCN. We were unable to demonstrate a significant difference in retinal input to those suprachiasmatic cells whichhad efferent projections to particular hypothalamic targets (SON and/or ARC), and those which did not.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 00:08:20