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Titolo:
Endothelial cell seeding on prosthetic surfaces
Autore:
Consigny, PM;
Indirizzi:
Thomas Jefferson Univ Hosp, Dept Radiol, Philadelphia, PA 19107 USA ThomasJefferson Univ Hosp Philadelphia PA USA 19107 elphia, PA 19107 USA Thomas Jefferson Univ, Jefferson Med Coll, Dept Physiol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA
Titolo Testata:
JOURNAL OF LONG-TERM EFFECTS OF MEDICAL IMPLANTS
fascicolo: 1-2, volume: 10, anno: 2000,
pagine: 79 - 95
SICI:
1050-6934(2000)10:1-2<79:ECSOPS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPANDED POLYTETRAFLUOROETHYLENE GRAFTS; CORONARY-ARTERY DISEASE; IN-STENT RESTENOSIS; NITRIC-OXIDE; VASCULAR GRAFTS; SMOOTH-MUSCLE; BALLOON ANGIOPLASTY; FLOW CONDITIONS; SAPHENOUS-VEIN; DACRON GRAFTS;
Keywords:
endothelium; stent; vascular graft; vascular prosthesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Consigny, PM Thomas Jefferson Univ Hosp, Dept Radiol, Suite 4200 Gibbon,111 S 11th St, Philadelphia, PA 19107 USA Thomas Jefferson Univ Hosp Suite 4200 Gibbon,111 S 11th St Philadelphia PA USA 19107
Citazione:
P.M. Consigny, "Endothelial cell seeding on prosthetic surfaces", J LONG-TE E, 10(1-2), 2000, pp. 79-95

Abstract

Once thought to be a monolayer of passive cells lining the vasculature, endothelial cells are now known to be important regulators of normal vascularphysiology. Unfortunately, these critically important cells are destroyed or removed by interventional and surgical procedures performed to recanalize or bypass vascular obstructions. The loss of these cells contributes to thrombosis and restenosis, the major complications observed after angioplasty, stent deployment, and prosthetic graft implantation. One approach to preventing these complications is the placement of endothelial cells on stentsor prosthetic grafts prior to their placement in vivo in the hope that these cells will, after growth and maturation, release the factors necessary to inhibit thrombosis and intimal thickening. The purpose of this review paper is to provide an overview of the physiologic functions of normal and dysfunctional endothelial cells, and to discuss experiments in which endothelial cells have been placed on metallic stents and prosthetic grafts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:44:54