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Titolo:
Angiogenesis: A "breakthrough" technology in cardiovascular medicine
Autore:
Isner, JM;
Indirizzi:
Tufts Univ, St Elizabeths Hosp, Ctr Med, Boston, MA 02135 USA Tufts Univ Boston MA USA 02135 abeths Hosp, Ctr Med, Boston, MA 02135 USA
Titolo Testata:
JOURNAL OF INVASIVE CARDIOLOGY
, volume: 12, anno: 2000, supplemento:, A
pagine: 14A - 17A
SICI:
1042-3931(200002)12:<14A:AA"TIC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; COLLATERAL VESSEL DEVELOPMENT; INTRAMUSCULAR GENE-TRANSFER; RECEPTOR EXPRESSION; HEART-DISEASE; IN-VIVO; PHVEGF(165); ISCHEMIA; LIMB; IMPAIRMENT;
Keywords:
neovascularization; therapeutic angiogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Isner, JM Tufts Univ, St Elizabeths Hosp, Ctr Med, 736 Cambridge St, Boston, MA 02135 USA Tufts Univ 736 Cambridge St Boston MA USA 02135 on, MA 02135 USA
Citazione:
J.M. Isner, "Angiogenesis: A "breakthrough" technology in cardiovascular medicine", J INVAS CAR, 12, 2000, pp. 14A-17A

Abstract

The identification of angiogenic growth factors has generated the opportunity for novel therapies in the treatment of a variety of diseases, Antibodies and/or naturally occurring angiogenesis inhibitors are being investigated clinically to antagonize key angiogenic factors, The strategy is designedto eliminate the vascular infrastructure and thereby minimize the extent of pathological consequences to the patient, A complimentary strategy is likely to emerge for the treatment of cardiovascular diseases, Clinical trialsof therapeutic angiogenesis have already been initiated in patients with myocardial ischemia and peripheral vascular disease. These include trials ofrecombinant protein therapy as well as gene transfer. While preliminary applications of gene therapy have established proof of the concept that angiogenic growth factors can augment collateral artery development in human subjects, many questions remain to be answered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:54:25