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Titolo:
Sleep-related breathing disorder is an independent risk factor for uncontrolled hypertension
Autore:
Grote, L; Hedner, J; Peter, JH;
Indirizzi:
Sahlgrens Univ Hosp, Dept Clin Pharmacol & Sleep Lab, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden Univ Marburg, Sleep Disorders Ctr, D-35032 Marburg, Germany Univ Marburg Marburg Germany D-35032 rders Ctr, D-35032 Marburg, Germany
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 6, volume: 18, anno: 2000,
pagine: 679 - 685
SICI:
0263-6352(200006)18:6<679:SBDIAI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITIVE AIRWAY PRESSURE; BLOOD-PRESSURE; SYSTEMIC HYPERTENSION; DRUG-THERAPY; APNEA; POPULATION; EXPERIENCE; CATECHOLAMINES; HYPERSOMNIA; MORTALITY;
Keywords:
sleep apnoea; hypertension; control of hypertension; risk factor; treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Grote, L Sahlgrens Univ Hosp, Dept Clin Pharmacol, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 othenburg, Sweden
Citazione:
L. Grote et al., "Sleep-related breathing disorder is an independent risk factor for uncontrolled hypertension", J HYPERTENS, 18(6), 2000, pp. 679-685

Abstract

Objective To test the hypothesis that sleep-related breathing disorder (SRBD) is associated with poor blood pressure control in hypertensive patientsindependent from confounding factors such as age, body mass index, alcohol, smoking and daytime blood gases. Design and methods This cross-sectional study of a sleep laboratory cohortwas carried out at the University Hospital Sleep Disorders Centre, Marburg. The study comprised 599 patients referred for a sleep study, all of them with a documented history of systemic hypertension and/or previously initiated antihypertensive therapy. Data were obtained from a clinical interview,two unattended sleep studies and assessment of clinic blood pressure, cholesterol level, alcohol and nicotine consumption and daytime blood gases. The main outcome measure was a post hoc analysis of predictors for poor bloodpressure control. Results Respiratory disturbance index (RDI) was significantly higher in patients with uncontrolled hypertension (blood pressure greater than or equalto 160 and/or 95 mmHg, n = 463) than in those with controlled hypertension(n = 136) (34.0 +/- 26.8 versus 27.0 +/- 23.5, P < 0.01). The relative proportion of patients with uncontrolled hypertension increased significantly as SRBD activity increased (chi(2), p < 0.05). Body mass index was the onlyindependent predictor (P = 0.006) of uncontrolled hypertension in the whole study sample. However, in the subset of patients aged less than or equal to 50 years, RDI (P = 0.006) and age (P = 0.016) were the only independent predictors. The probability of uncontrolled hypertension increased by approximately 2% (B = 0.019, P = 0.006) for each RDI unit. Conclusion SRBD should be considered, in addition to traditional confounders, as a risk factor for poor blood pressure control in younger hypertensive patients (less than or equal to 50 years of age). J Hypertens 2000, 18:679-685 (C) Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 03:06:20