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Titolo:
Signaling pathways to the assembly of an interferon-beta enhanceosome - Chemical genetic studies with a small molecule
Autore:
Kim, T; Kim, TY; Lee, WG; Yim, J; Kim, TK;
Indirizzi:
Seoul Natl Univ, Inst Mol Biol & Genet, Natl Creat Res Initiat Ctr Genet Reprogramming, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea151742 ming, Seoul 151742, South Korea Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Inst Chem & Cell Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 t Chem & Cell Biol, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 22, volume: 275, anno: 2000,
pagine: 16910 - 16917
SICI:
0021-9258(20000602)275:22<16910:SPTTAO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; REGULATORY FACTOR-3; TRANSCRIPTIONAL SYNERGY; MEK KINASE-1; DNA-DAMAGE; IN-VITRO; ACTIVATION; PROTEIN; P53; TRANSDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, TK Seoul Natl Univ, Inst Mol Biol & Genet, Natl Creat Res Initiat CtrGenet Reprogramming, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 oul 151742, South Korea
Citazione:
T. Kim et al., "Signaling pathways to the assembly of an interferon-beta enhanceosome - Chemical genetic studies with a small molecule", J BIOL CHEM, 275(22), 2000, pp. 16910-16917

Abstract

Small molecules that modulate specific protein functions are valuable tools for dissecting complex signaling pathways. Here, we identified a small molecule that induces the assembly of the interferon-beta (IFN-beta) enhanceosome by stimulating all the enhancer-binding activator proteins: ATF2/c-JUN, IRF3, and p50/p65 of NF-kappa B. This compound stimulates mitogen-activated protein kinase kinase kinase 1 (MEKK1), which is a member of a family ofproteins involved in stress-mediated signaling pathways. Consistent with this, MEKK1 activates IRF3 in addition to ATF2/c-JUN and NF-kappa B for the assembly of the IFN-beta enhanceosome. MEKK1 activates IRF3 through the c-JUN amino-terminal kinase (JNK) pathway but not the p38 and I kappa B kinase(IKK) pathway. Taken together with previous observations, these results implicate that, for the assembly of an IFN-beta enhanceosome, MEKK1 can induce IRF3 and ATF2/c-JUN through the JNK pathway, whereas it can induce NF-kappa B through the IKK pathway. Thus, specific MEKK family proteins may be able to integrate some of multiple signal transduction pathways leading to the specific activation of the IFN-beta enhanceosome.

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Documento generato il 03/06/20 alle ore 00:06:15