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Titolo:
Cerebrospinal fluid antibodies directed against neuron-associated gangliosides in HIV-1 infection
Autore:
Gisslen, M; Lekman, A; Fredman, P;
Indirizzi:
Sahlgrens Univ Hosp, Inst Internal Med, Dept Infect Dis, S-41685 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41685 S-41685 Gothenburg, Sweden Sahlgrens Univ Hosp, Inst Clin Neurosci, Dept Psychiat & Neurochem, S-41685 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41685 S-41685 Gothenburg, Sweden
Titolo Testata:
INFECTION
fascicolo: 3, volume: 28, anno: 2000,
pagine: 143 - 148
SICI:
0300-8126(200005/06)28:3<143:CFADAN>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIDS DEMENTIA COMPLEX; HUMAN-IMMUNODEFICIENCY-VIRUS; CENTRAL-NERVOUS-SYSTEM; BLOOD-BRAIN-BARRIER; NEUROLOGICAL DISORDERS; PROTEIN; MARKERS; IGG;
Keywords:
HIV-(1); cerebrospinal fluid; anti-ganglioside antibodies; neuron;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Gisslen, M Sahlgrens Univ Hosp, Inst Internal Med, Dept Infect Dis, S-41685 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41685 henburg, Sweden
Citazione:
M. Gisslen et al., "Cerebrospinal fluid antibodies directed against neuron-associated gangliosides in HIV-1 infection", INFECTION, 28(3), 2000, pp. 143-148

Abstract

Background: Loss of synapses and neurons is a common finding in HIV-1 infection. Since the in vivo infection of neurons by HIV-1 is limited, indirectfactors are likely to contribute to the pathogenesis,Patients and Methods: We have analyzed cerebrospinal fluid (CSF) and serumsamples from 25 HIV-1-infected individuals (nine with and 16 without CNS complications) and 19 HIV-negative controls with aseptic meningitis or viralencephalitis, for the presence of antibodies directed against the neuron-associated gangliosides GM1, GD1a and GD1b. Results: Positive antibody titers to greater than or equal to 1 of the gangliosides were found in 13/25 HIV-1-infected patients in CSF and in 17/25 in serum. Significant correlations were found between the presence and titers of CSF antibodies against GM1, GD1a, and GD1b. Six out of nine patients with, and 3/16 without neurological complications (p < 0.05) had positive CSF titers of greater than or equal to 1 of the ganglioside antibodies combined with negative serum titers, indicating intrathecal antibody production. In contrast, only 1/19 controls had detectable anti-ganglioside antibodies in the CSF. Conclusion: The results should be interpreted with caution and CSF anti-ganglioside antibody production might be a part of a non-specific intrathecalpolyclonal immunoactivation. Nevertheless, autoantibodies directed againstneuron-associated gangliosides might be involved in the neuropathogenesis in HIV-1 disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 02:17:00