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Titolo:
The role of the Brambell receptor (FcRB) in liver: protection of endocytosed immunoglobulin G (IgG) from catabolism in hepatocytes rather than transport of IgG to bile
Autore:
Telleman, P; Junghans, RP;
Indirizzi:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol, Boston, MA 02215 USA Harvard Univ Boston MA USA 02215 Div Hematol Oncol, Boston, MA 02215 USA Harvard Univ, Sch Med, Harvard Inst Human Genet, Biotherapeut Dev Lab, Boston, MA 02215 USA Harvard Univ Boston MA USA 02215 otherapeut Dev Lab, Boston, MA 02215 USA
Titolo Testata:
IMMUNOLOGY
fascicolo: 2, volume: 100, anno: 2000,
pagine: 245 - 251
SICI:
0019-2805(200006)100:2<245:TROTBR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-RELATED RECEPTOR; ANTIBODY TRANSPORT; HUMAN PLACENTA; MICE; SERUM; MHC; COMPLEX; LOCALIZATION; PROTEINS; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Junghans, RP Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol, HIM 403, Boston, MA 02215 USA Harvard Univ HIM 403 Boston MA USA 02215 Boston, MA 02215 USA
Citazione:
P. Telleman e R.P. Junghans, "The role of the Brambell receptor (FcRB) in liver: protection of endocytosed immunoglobulin G (IgG) from catabolism in hepatocytes rather than transport of IgG to bile", IMMUNOLOGY, 100(2), 2000, pp. 245-251

Abstract

The Brambell receptor (FcRB) mediates functions of both immunoglobulin G (IgG) transport, transmitting immunity from mother to young, and IgG protection, making IgG the longest surviving of all plasma proteins. Reflecting its role as transport receptor (termed FcRn, for neonatal rat intestine, the tissue from which it was first cloned), FcRB is expressed antenatally in the rabbit, mouse and rat fetal yolk sac and in human placental syncytiotrophoblasts, and neonatally in the intestinal epithelium of mice and rats. Reflecting its role as protection receptor (FcRp), FcRB is expressed in the vascular endothelium throughout life, where it protects IgG from the on-going catabolic activities of this tissue. FcRB detected in hepatocytes was hypothesized to mediate transport of IgG from serum to bile, thus potentially extending the transport expression (FcRn) of this receptor beyond the perinatal period. Our results show serum-to-bile transport of IgG to be unaffectedin mice functionally deleted for FcRB. Accordingly, the hypothesis is rejected that FcRB functions as transport receptor (FcRn) in liver. The defaultconclusion is that FcRB in hepatocytes functions as FcRp, serving to protect IgG from catabolism in hepatocytes that accompanies the endocytic activity of these cells. We conclude that there remains to date no evidence of anFcRn-like transport function of the Brambell receptor beyond the perinatalperiod, after which the FcRp function of the receptor predominates, paralleling the endocytic activities of the associated tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:05:51