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Titolo:
Ear and bearing in relation to genotype and growth in Turner syndrome
Autore:
Barrenas, ML; Landin-Wilhelmsen, K; Hanson, C;
Indirizzi:
Univ Gothenburg, Sahlgrens Univ Hosp, Dept Audiol, SE-41345 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden SE-41345 , SE-41345 Gothenburg, Sweden Univ Gothenburg, Sahlgrens Univ Hosp, Res Ctr Endocrinol & Metab, SE-41345Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden SE-41345 b, SE-41345Gothenburg, Sweden Univ Gothenburg, Sahlgrens Univ Hosp, Dept Obstet & Gynaecol, SE-41345 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden SE-41345 , SE-41345 Gothenburg, Sweden
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 144, anno: 2000,
pagine: 21 - 28
SICI:
0378-5955(200006)144:1-2<21:EABIRT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOWNS-SYNDROME; OTITIS-MEDIA; INNER-EAR; EUSTACHIAN-TUBE; SHORT STATURE; HEARING-LOSS; FACTOR-I; CHILDREN; WOMEN; SKULL;
Keywords:
Turner syndrome; hearing; chromosome; insulin-like growth factor-1; body height; cell cycle delay hypothesis; Down syndrome; aneuploidy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Barrenas, ML Univ Gothenburg, Sahlgrens Univ Hosp, Dept Audiol, SE-41345 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden SE-41345 thenburg, Sweden
Citazione:
M.L. Barrenas et al., "Ear and bearing in relation to genotype and growth in Turner syndrome", HEARING RES, 144(1-2), 2000, pp. 21-28

Abstract

Hearing loss, auricular anomalies and middle ear infections are common findings in many genetic disorders, but the mechanisms have remained unknown. We studied ear and hearing problems in Turner's syndrome (TS) in relation to the degree of X chromosome loss (i.e, degree of mosaicism) and growth. One hundred and nineteen girls and women with TS were studied regarding audiometry, fluorescent in situ hybridisation, serum concentration of insulin-like growth factor-1 (IGF-1) and body height. It was found that sensorineuralhearing loss and occurrence of auricular anomalies were significantly increased the greater the proportion of 45,X cells in a particular individual (P < 0.05 and P < 0.001, respectively). Middle ear infections and sensorineural hearing loss were negatively correlated with IGF-1 (P < 0.05 and P < 0.001. respectively). Hearing correlated positively with height (P < 0.01) and IGF-1 independently of age (P < 0.05). Height correlated positively with IGF-1 (P ( 0.001). Auricular malformations, middle ear infections and hearing impairment in TS were interpreted as due to growth disturbances during development. A new hypothesis on the pathophysiology of external, middle andinner ear disorders due to a delayed cell cycle caused by chromosomal aberrations per se and not only to the specific X chromosome deletion is presented. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:00:33