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Titolo:
Dll4, a novel Notch ligand expressed in arterial endothelium
Autore:
Shutter, JR; Scully, S; Fan, W; Richards, WG; Kitajewski, J; Deblandre, GA; Kintner, CR; Stark, KL;
Indirizzi:
Amgen Inc, Dept Mol Genet, Thousand Oaks, CA 91320 USA Amgen Inc ThousandOaks CA USA 91320 l Genet, Thousand Oaks, CA 91320 USA Amgen Inc, Dept Pathol, Thousand Oaks, CA 91320 USA Amgen Inc Thousand Oaks CA USA 91320 Pathol, Thousand Oaks, CA 91320 USA Amgen Inc, Dept Neurobiol, Thousand Oaks, CA 91320 USA Amgen Inc ThousandOaks CA USA 91320 urobiol, Thousand Oaks, CA 91320 USA Columbia Univ Coll Phys & Surg, Dept Pathol & OB GYN, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 90037 USA Salk Inst Biol Studies La Jolla CA USA 90037 Lab, La Jolla, CA 90037 USA
Titolo Testata:
GENES & DEVELOPMENT
fascicolo: 11, volume: 14, anno: 2000,
pagine: 1313 - 1318
SICI:
0890-9369(20000601)14:11<1313:DANNLE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
XENOPUS-EMBRYOS; NEURAL INDUCTION; DELTA-HOMOLOG; CELL FATE; PRIMARY NEUROGENESIS; ALAGILLE-SYNDROME; DROSOPHILA NOTCH; JAGGED1 GENE; IDENTIFICATION; EMBRYOGENESIS;
Keywords:
Notch signaling pathway; endothelium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Stark, KL Amgen Inc, Dept Mol Genet, Thousand Oaks, CA 91320 USA Amgen Inc Thousand Oaks CA USA 91320 housand Oaks, CA 91320 USA
Citazione:
J.R. Shutter et al., "Dll4, a novel Notch ligand expressed in arterial endothelium", GENE DEV, 14(11), 2000, pp. 1313-1318

Abstract

We report the cloning and characterization of a new member of the Delta family of Notch ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a membrane-bound ligand, characterized by an extracellular region containing several EGF-like domains and a DSL domain required for receptor binding. In situ analysis reveals a highly selective expression pattern of Dll4 within the vascular endothelium. The activity and expression of Dll4 and the known actions of other members of this family suggest a role for Dll4 in the control of endothelial cell biology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:22:11