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Titolo:
Novel Dictyostelium unconventional myosin, MyoM, has a putative RhoGEF domain
Autore:
Oishi, N; Adachi, H; Sutoh, K;
Indirizzi:
Univ Tokyo, Grad Sch Arts & Sci, Dept Life Sci, Meguro Ku, Tokyo 1538902, Japan Univ Tokyo Tokyo Japan 1538902 Life Sci, Meguro Ku, Tokyo 1538902, Japan Teikyo Univ, Sch Med, Itabashi Ku, Tokyo 1738605, Japan Teikyo Univ Tokyo Japan 1738605 h Med, Itabashi Ku, Tokyo 1738605, Japan Teikyo Univ, Biotechnol Res Ctr, Miyamae Ku, Kawasaki, Kanagawa 2160001, Japan Teikyo Univ Kawasaki Kanagawa Japan 2160001 saki, Kanagawa 2160001, Japan
Titolo Testata:
FEBS LETTERS
fascicolo: 1, volume: 474, anno: 2000,
pagine: 16 - 22
SICI:
0014-5793(20000526)474:1<16:NDUMMH>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAVY-CHAIN GENE; GTPASE-ACTIVATING PROTEIN; P21-ACTIVATED KINASE; TEDS RULE; IN-VIVO; DISCOIDEUM; EXPRESSION; SEQUENCE; DISRUPTION; HOMOLOGY;
Keywords:
motor protein; myosin; Rho-type GTPase; GDP/GTP exchange factor; MyoM; Dictyostelium discoideum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Sutoh, K Univ Tokyo, Grad Sch Arts & Sci, Dept Life Sci, Meguro Ku, 3-8-1 Komaba, Tokyo 1538902, Japan Univ Tokyo 3-8-1 Komaba Tokyo Japan 1538902 Tokyo 1538902, Japan
Citazione:
N. Oishi et al., "Novel Dictyostelium unconventional myosin, MyoM, has a putative RhoGEF domain", FEBS LETTER, 474(1), 2000, pp. 16-22

Abstract

We have cloned a novel unconventional myosin gene myoM in Dictyostelium, Phylogenetic analysis of the motor domain indicated that MyoM does not belong to any known subclass of the myosin superfamily, Following the motor domain, two calmodulin-binding IQ motifs, a putative coiled-coil region, and a Pro, Ser and Thr-rich domain, lies a combination of dbl homology and pleckstrin homology domains, These are conserved in Rho GDP/GTP exchange factors (RhoGEFs), We have identified for the first time the RhoGEF domain in the myosin sequences. The growth and terminal developmental phenotype of Dictyostelium cells were not affected by the myoM- mutation. Green fluorescent protein-tagged MyoM, however, accumulated at cro,vn-shaped projections and membranes of phase lucent vesicles in growing cells, suggesting its possible roles in macropinocytosis. (C) 2000 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:06:19