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Titolo:
Common cytokine receptor gamma chain (gamma(c))-deficient B cells persist in T cell-deficient gamma(-)(c) mice and respond to a T-independent antigen
Autore:
Vosshenrich, CAJ; Sharara, LI; Guy-Grand, D; Rajewsky, K; Muller, W; Di Santo, JP;
Indirizzi:
Inst Pasteur, Unite Cytokines & Dev Lymphoide, F-75724 Paris, France Inst Pasteur Paris France F-75724 & Dev Lymphoide, F-75724 Paris, France Univ Cologne, Inst Genet, D-5000 Cologne, Germany Univ Cologne Cologne Germany D-5000 Inst Genet, D-5000 Cologne, Germany Hop Necker Enfants Malad, INSERM, U429, Paris, France Hop Necker Enfants Malad Paris France alad, INSERM, U429, Paris, France
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 6, volume: 30, anno: 2000,
pagine: 1614 - 1622
SICI:
0014-2980(200006)30:6<1614:CCRGC(>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE COMBINED IMMUNODEFICIENCY; C-KIT; INTERLEUKIN-7 RECEPTOR; LYMPHOID DEVELOPMENT; LINEAGE CELLS; IL-2 RECEPTOR; GROWTH; LYMPHOCYTES; PROGENITORS; DIFFERENTIATION;
Keywords:
interleukin; immunodeficiency; gene targeted mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Di Santo, JP Inst Pasteur, Unite Cytokines & Dev Lymphoide, 25 Rue Dr Roux, F-75724 Paris, France Inst Pasteur 25 Rue Dr Roux Paris France F-75724 ris, France
Citazione:
C.A.J. Vosshenrich et al., "Common cytokine receptor gamma chain (gamma(c))-deficient B cells persist in T cell-deficient gamma(-)(c) mice and respond to a T-independent antigen", EUR J IMMUN, 30(6), 2000, pp. 1614-1622

Abstract

Defects in the common cytokine receptor gamma chain (gamma(c)) in man result in X-linked severe combined immunodeficiency disease (SCIDX1) characterized by an absence of alpha beta T cells, gamma delta T cells and NK cells, with the presence of circulating B cells. Mice made deficient for gamma(c) lack gamma delta T cells and NK cells, but in contrast to SCIDX1 patients have appreciable numbers of alpha beta T cells, while B cells are reduced about tenfold in numbers and disappear with age, Here we show that when gamma(c)(-) mice are rendered T cell deficient, B cell numbers are still reducedbut the age-dependent loss of B cells does not occur. The peripheral B cells which persisted in gamma(c)(-)/nude and gamma(c)(-)/TCR beta(-/-) mice were able to respond to mitogen stimulation in Vitro and to mount antigen-specific T-independent Ig responses in vivo. These results demonstrate that gamma(c)(-) B cells are functionally competent and suggest that residual alpha beta T cells are implicated in the B cell loss in gamma(c) mice. The gamma(c)(-)/nude and gamma(c)(-)/TCR beta(-/-) mice provide new models to dissect the role of gamma(c)-dependent receptors during murine B cell differentiation.

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Documento generato il 23/09/20 alle ore 22:01:46