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Titolo:
Accumulation of identical T cell clones in the right and left lobes of thethyroid gland in patients with Graves' disease: Analysis of T cell clonotype in vivo
Autore:
Sekine, T; Kato, R; Kato, T; Masuko-Hongo, K; Kameko, F; Maruyama, M; Nishioka, K; Yamamoto, K;
Indirizzi:
St Marianna Univ, Inst Med Sci, Rheumatol Immunol & Genet Program, MiyamaeKu, Kawasaki, Kanagawa 2168512, Japan St Marianna Univ Kawasaki Kanagawa Japan 2168512 Kanagawa 2168512, Japan Mitsubishi Kagaku Bioclin Labs Inc, Itabashi Ku, Tokyo 1748555, Japan Mitsubishi Kagaku Bioclin Labs Inc Tokyo Japan 1748555 yo 1748555, Japan Shinshu Univ, Sch Allied Med Sci, Dept Med Technol, Matsumoto, Nagano 3908621, Japan Shinshu Univ Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan Shinshu Univ, Sch Med, Dept Surg 2, Matsumoto, Nagano 3908621, Japan Shinshu Univ Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 heumatol, Bunkyo Ku, Tokyo 1130033, Japan
Titolo Testata:
ENDOCRINE JOURNAL
fascicolo: 2, volume: 47, anno: 2000,
pagine: 127 - 136
SICI:
0918-8959(200004)47:2<127:AOITCC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATING HORMONE-RECEPTOR; GENE USAGE; AUTOIMMUNE-DISEASE; EPITHELIAL-CELLS; ANTIGEN; AUTOANTIGEN; TISSUE; EXPRESSION; REGION; SUSCEPTIBILITY;
Keywords:
Graves' disease; intrathyroidal T cell; T cell clonotype; RT-PCR-SSCP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kato, T St Marianna Univ, Inst Med Sci, Rheumatol Immunol & Genet Program,MiyamaeKu, 2-16-1 Sugao, Kawasaki, Kanagawa 2168512, Japan St Marianna Univ 2-16-1 Sugao Kawasaki Kanagawa Japan 2168512 apan
Citazione:
T. Sekine et al., "Accumulation of identical T cell clones in the right and left lobes of thethyroid gland in patients with Graves' disease: Analysis of T cell clonotype in vivo", ENDOCR J, 47(2), 2000, pp. 127-136

Abstract

To elucidate the involvement of intrathyroidal T cells in the thyroid antigen-specific immune response in Graves' disease (GD), we investigated whether identical T cell clonotypes accumulate clonally in the right and left lobes of thyroid glands of GD patients. mRNAs extracted from thyroid glands of five females patients with GD were reverse-transcribed to cDNA and then the genes coding the T cell receptor B chain variable (V-NDN-J) region were amplified using polymerase chain reaction. Single strand conformation polymorphism analysis and subsequently nucleotide sequencing were also performedto determine the clonotype of accumulating T cells. T cells infiltrating the thyroid glands showed oligoclonal expansion. The expanded T cell clonotypes were not detected in peripheral blood of the same patients. Importantly, the majority of expanding T cell clonotypes in the two lobes of the thyroid glands were identical, our findings suggest that the clonal expansion ofidentical T cell clonotypes in the two lobes is driven by factors common to both lobes, such as thyroid-specific antigens, in patients with Graves' disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 06:35:50