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Titolo:
Variables of the insulin resistance syndrome are associated with reduced arterial distensibility in healthy non-diabetic middle-aged women
Autore:
van Popele, NM; Westendorp, ICD; Bots, ML; Reneman, RS; Hoeks, APG; Hofman, A; Grobbee, DE; Witteman, JCM;
Indirizzi:
Erasmus Univ, Sch Med, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Univ Med Ctr Utrecht, Julius Ctr Patient Oriented Res, Utrecht, Netherlands Univ Med Ctr Utrecht Utrecht Netherlands nted Res, Utrecht, Netherlands Maastricht Univ, Cardiovasc Res Inst Maastricht, Dept Physiol, Maastricht,Netherlands Maastricht Univ Maastricht Netherlands Physiol, Maastricht,Netherlands Maastricht Univ, Cardiovasc Res Inst Maastricht, Dept Biophys, Maastricht,Netherlands Maastricht Univ Maastricht Netherlands Biophys, Maastricht,Netherlands
Titolo Testata:
DIABETOLOGIA
fascicolo: 5, volume: 43, anno: 2000,
pagine: 665 - 672
SICI:
0012-186X(200005)43:5<665:VOTIRS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY LIPOPROTEIN CHOLESTEROL; GLYCATION END-PRODUCTS; COMMON CAROTID-ARTERY; PULSE-WAVE VELOCITY; RISK-FACTORS; AORTIC COMPLIANCE; BLOOD-PRESSURE; ATHEROSCLEROSIS; STIFFNESS; DISEASE;
Keywords:
insulin resistance; arterial stiffness; healthy subjects; women; population;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Witteman, JCM Erasmus Univ, Sch Med, Dept Epidemiol & Biostat, Dr Molewaterpl 50,POB 1738, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Dr Molewaterpl 50,POB 1738 Rotterdam Netherlands NL-3000 DR
Citazione:
N.M. van Popele et al., "Variables of the insulin resistance syndrome are associated with reduced arterial distensibility in healthy non-diabetic middle-aged women", DIABETOLOG, 43(5), 2000, pp. 665-672

Abstract

Aims/hypothesis. The insulin resistance syndrome is related to arterial stiffness in diabetic subjects. Whether the insulin resistance syndrome is also related to arterial stiffness in non-diabetic subjects is less clear. Westudied the association between variables of the insulin resistance syndrome in relation to arterial distensibility in healthy middle-aged non-diabetic women. Methods. This study was done in 180 non-diabetic women, aged 43-55, selected from the general population. Arterial distensibility was assessed in thecarotid artery. The associations were evaluated using linear regression analyses. Results. Strong associations were found between arterial distensibility and the variables of the insulin resistance syndrome: body mass index, waist-to-hip ratio, high-density-lipoprotein-cholesterol, triglycerides, glucose,insulin, apolipoprotein A1, plasminogen activator inhibitor-1-antigen and tissue-type plasminogen activator-antigen. After additional adjustment for mean arterial pressure, common carotid arterial distensibility remained associated with body mass index: beta-coefficient (95 % confidence interval) per kg/m(2): -0.24 (-0.42, -0.06); waist-to-hip ratio: -26.62 (-40.59; -12.65) per m/m; triglycerides: -1.42(-2.77; -0.08) per mmol/l; plasminogen activator inhibitor-1-antigen: -0.01 (-0.02, -0.00) per ng/ml and borderline significant associated with high-density-lipoprotein-cholesterol: 1.93 (-0.01; 3.87; p = 0.07) per mmol/l. Clustering of variables of the insulin resistance syndrome was strongly related to decreased arterial distensibility which remained after adjustment for mean arterial pressure. No association wasfound between arterial distensibility and variables that are not part of the insulin resistance syndrome: total cholesterol, LDL-cholesterol and apolipoprotein B. Conclusion/interpretation. The results of this study show that variables of the insulin resistance syndrome are associated with decreased arterial distensibility of the common carotid artery in healthy non-diabetic subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 09:34:18