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Titolo:
Increased mortality in Type I diabetic patients using sulphonylurea and metformin in combination: a population-based observational study
Autore:
Olsson, J; Lindberg, G; Gottsater, M; Lindwall, K; Sjostrand, A; Tisell, A; Melander, A;
Indirizzi:
Malmo Univ Hosp, Med Res Ctr, NEPI Fdn, S-20502 Malmo, Sweden Malmo Univ Hosp Malmo Sweden S-20502 tr, NEPI Fdn, S-20502 Malmo, Sweden Vetlanda Hlth Care Ctr, Vetlanda, Sweden Vetlanda Hlth Care Ctr VetlandaSweden Hlth Care Ctr, Vetlanda, Sweden Tranas Hlth Care Ctr, TRanas, Sweden Tranas Hlth Care Ctr TRanas SwedenTranas Hlth Care Ctr, TRanas, Sweden
Titolo Testata:
DIABETOLOGIA
fascicolo: 5, volume: 43, anno: 2000,
pagine: 558 - 560
SICI:
0012-186X(200005)43:5<558:IMITID>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-GLUCOSE CONTROL; COMPLICATIONS;
Keywords:
Type II diabetes; pharmacoepidemiology; sulphonylurea; metformin; combination treatment; mortality;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Olsson, J Malmo Univ Hosp, Med Res Ctr, NEPI Fdn, S-20502 Malmo, Sweden Malmo Univ Hosp Malmo Sweden S-20502 dn, S-20502 Malmo, Sweden
Citazione:
J. Olsson et al., "Increased mortality in Type I diabetic patients using sulphonylurea and metformin in combination: a population-based observational study", DIABETOLOG, 43(5), 2000, pp. 558-560

Abstract

Aims/hypothesis. This study analysed cause-specific mortality in Type II (non-insulin-dependent) diabetic patients using either sulphonylurea alone or in combination with metformin. Methods. Patients were followed from the first day they were taking eitherthe combination or sulphonylurea alone. Odds ratios by Cox regression analyses were adjusted for age, sex, duration of diabetes, study area, year of inclusion and fasting blood glucose at inclusion. Results. We included 169 patients taking sulphonylurea and metformin in combination and 741 patients taking only sulphonylurea. Mean (range) follow-up time was 6.1 (0.1-13.0) years. The adjusted odds ratio for overall mortality was 1.63 (95 % confidence interval 1.27-2.09) in patients taking sulphonylurea and metformin combination vs those using sulphonylurea alone. For mortality from ischaemic heart disease and stroke the adjusted odds ratios were 1.73 (95 % confidence interval 1.17-2.55) and 2.33 (95 % confidence interval 1.17-4.63), respectively. Conclusion/interpretation. There was a higher cardiovascular mortality in Type II diabetic patients taking sulphonylurea and metformin in combinationthan in those taking only sulphonylurea. Hence, it cannot be excluded thatthis kind of combination therapy possibly increases cardiovascular mortality. It is feasible that the increased mortality was secondary to a more aggressive type of diabetes in the patients using sulphonylurea and metformin in combination. Combination therapy is known to promote additional blood glucose reduction but there is as yet no evidence that a sulphonylurea and metformin combination is more beneficial on micro- or macrovascular disease than sulphonylurea or metformin alone.

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Documento generato il 22/01/20 alle ore 18:41:17