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Titolo:
Drosophila arc encodes a novel adherens junction-associated PDZ domain protein required for wing and eye development
Autore:
Liu, XJ; Lengyel, JA;
Indirizzi:
Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA RW Johnson Pharmaceut Res Inst, San Diego, CA 92121 USA RW Johnson Pharmaceut Res Inst San Diego CA USA 92121 Diego, CA 92121 USA
Titolo Testata:
DEVELOPMENTAL BIOLOGY
fascicolo: 2, volume: 221, anno: 2000,
pagine: 419 - 434
SICI:
0012-1606(20000515)221:2<419:DAEANA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEGMENT-POLARITY GENE; TOLL GENE; PATTERN-FORMATION; MOLECULAR-BASIS; CELL-TYPES; MELANOGASTER; MORPHOGENESIS; EMBRYO; ORGANIZATION; EXPRESSION;
Keywords:
adherens junction; morphogenetic furrow; morphogenesis; cell rearrangement;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Lengyel, JA Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Box 951606, Los Angeles,CA 90095 USA Univ Calif Los Angeles Box 951606 Los Angeles CA USA 90095 USA
Citazione:
X.J. Liu e J.A. Lengyel, "Drosophila arc encodes a novel adherens junction-associated PDZ domain protein required for wing and eye development", DEVELOP BIO, 221(2), 2000, pp. 419-434

Abstract

Loss of are function results in a downwardly curved wing and smaller eyes with a reduced number of ommatidia. Consistent with this phenotype, molecular analysis shows that are mRNA and protein are expressed in the wing imaginal disc and in clusters of cells in the morphogenetic furrow of the eye imaginal disc. The 36-kb are transcription unit contains 10 exons that are spliced to form a 5.5-kb mRNA. The encoded Are protein is 143,000 Da and contains two PDZ (PSD-95, Discs large, ZO-1) domains; there is no close structural similarity to other PDZ proteins. In addition to its expression in imaginal discs, are is expressed during embryogenesis in epithelia undergoing morphogenesis, including the invaginating posterior midgut, evaginating Malpighian tubule buds, elongating hindgut, invaginating salivary glands, intersegmental grooves, and developing tracheae. Are. protein colocalizes with Armadillo (beta-catenin) to the apical (luminal) surface of these developingepithelia, indicating that it is associated with adherens junctions. Genesthat are required for patterning of embryonic epithelia (e.g., tailless, Kruggel, fork head, and brachyenteron) or for progression of the morphogenetic furrow (i. e., hedgehog) are required to establish or maintain the regional expression of are. Misexpression of are in the eye imaginal discs results in rough and larger eyes with fused ommatidia. We propose that are affects eye development by modulating adherens junctions of the developing ommatidium. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 00:25:39