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Titolo:
Procalcitonin and calcitonin gene-related peptide decrease LPS-induced TNFproduction by human circulating blood cells
Autore:
Monneret, G; Pachot, A; Laroche, B; Picollet, J; Bienvenu, J;
Indirizzi:
Ctr Hosp Lyon Sud, Immunol Lab, F-69495 Pierre Benite, France Ctr Hosp Lyon Sud Pierre Benite France F-69495 495 Pierre Benite, France
Titolo Testata:
CYTOKINE
fascicolo: 6, volume: 12, anno: 2000,
pagine: 762 - 764
SICI:
1043-4666(200006)12:6<762:PACGPD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEPSIS;
Keywords:
calcitonin gene-related peptide; procalcitonin; tumour necrosis factor-alpha; septic shock;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Bienvenu, J Ctr Hosp Lyon Sud, Immunol Lab, F-69495 Pierre Benite, France Ctr Hosp Lyon Sud Pierre Benite France F-69495 enite, France
Citazione:
G. Monneret et al., "Procalcitonin and calcitonin gene-related peptide decrease LPS-induced TNFproduction by human circulating blood cells", CYTOKINE, 12(6), 2000, pp. 762-764

Abstract

The pathogenesis of septic shock is mainly due to unregulated tumour necrosis factor-alpha (TNF-alpha) production. Procalcitonin (PCT) and calcitoningene-related peptide (CGRP) are alternative transcription products of the calcitonin gene. Since high PCT levels have been described in human sepsis,and since CGRP inhibits TNF synthesis in rats, we examined the role of these peptides in the regulation of the inflammatory response during septic shock. LPS-induced TNF production was assessed using a human whole blood model. In this model, PCT (10 (- 7) M) and CGRP (10 (- 6) M) significantly inhibit TNF production by 27 and 24 % respectively. The effect of CGRP was reversed by CGRP 8-37 (10 mu M), an antagonist of CGRP receptor. No effect on interleukin (IL)-1, IL-6 and IL-8 was found. This is the first description of an anti-inflammatory role for PCT and CGRP in humans. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:38:04