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Titolo:
Effects of an intravenous catheter on the local production of cytokines and soluble cytokine receptors in healthy men
Autore:
Haack, M; Reichenberg, A; Kraus, T; Schuld, A; Yirmiya, R; Pollmacher, T;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany Hebrew Univ Jerusalem, Jerusalem, Israel Hebrew Univ Jerusalem JerusalemIsrael niv Jerusalem, Jerusalem, Israel
Titolo Testata:
CYTOKINE
fascicolo: 6, volume: 12, anno: 2000,
pagine: 694 - 698
SICI:
1043-4666(200006)12:6<694:EOAICO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; DIURNAL-VARIATIONS; RAT-BRAIN; CIRCADIAN RHYTHMOMETRY; MESSENGER-RNA; PLASMA-LEVELS; TNF-ALPHA; INTERLEUKIN-6; IL-6; RHYTHMS;
Keywords:
diurnal variations; IL-6; intravenous catheter; soluble TNF receptors; TNF-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Pollmacher, T Max Planck Inst Psychiat, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
M. Haack et al., "Effects of an intravenous catheter on the local production of cytokines and soluble cytokine receptors in healthy men", CYTOKINE, 12(6), 2000, pp. 694-698

Abstract

Like many aspects of physiology, functions of the immune system show considerable diurnal variation. Studies investigating diurnal variations in the circulating amounts of cytokines, in general, used blood samples obtained from an intravenous catheter, The results of such studies may be confounded by an effect of the catheter on local cytokine production. We measured the levels of IL-6, tumour necrosis factor alpha (TNF-alpha) and soluble TNF receptors (sTNF-R) p55 and p75 in 20 healthy men between 09:00 and 19:00 h inplasma samples obtained from an intravenous catheter and in one additionalsample obtained by a simple needle stick in the contralateral arm 10 h after baseline. In plasma from the catheter the levels of IL-6 increased significantly over time, TNF-alpha levels slightly decreased and the time courses of TNF receptor levels showed significant trends of a higher order. Control levels of IL-6, TNF-alpha and sTNF-R p75 measured in plasma obtained by needle stick after 10 h did not differ from baseline, and those of sTNF-R p55 were even higher. We conclude that local alterations in the production of cytokines and soluble cytokine receptors induced by an intravenous catheter represent an important confounding factor for studies investigating diurnal variations in immune functions. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:16:59