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Titolo:
Carbohydrate based vaccines
Autore:
Kuberan, B; Lindhardt, RJ;
Indirizzi:
Univ Iowa, Dept Chem & Biochem Engn, Dept Chem, Div Med & Nat Prod Chem, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 & Nat Prod Chem, Iowa City, IA 52242 USA
Titolo Testata:
CURRENT ORGANIC CHEMISTRY
fascicolo: 6, volume: 4, anno: 2000,
pagine: 653 - 677
SICI:
1385-2728(200006)4:6<653:CBV>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; GROUP-B STREPTOCOCCUS; KEYHOLE LIMPET HEMOCYANIN; CAPSULAR POLYSACCHARIDE ANTIGEN; ALTERNATIVE COMPLEMENT PATHWAY; SHIGELLA-DYSENTERIAE TYPE-1; NUCLEAR MAGNETIC-RESONANCE; O-SPECIFIC POLYSACCHARIDE; TUMOR-ASSOCIATED ANTIGEN; SOLID-PHASE SYNTHESIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
125
Recensione:
Indirizzi per estratti:
Indirizzo: Lindhardt, RJ Univ Iowa, Dept Chem & Biochem Engn, Dept Chem, Div Med & Nat Prod Chem, Phar S 328, Iowa City, IA 52242 USA Univ Iowa Phar S 328 Iowa City IA USA 52242 ty, IA 52242 USA
Citazione:
B. Kuberan e R.J. Lindhardt, "Carbohydrate based vaccines", CURR ORG CH, 4(6), 2000, pp. 653-677

Abstract

Vaccination is the most cost-efficient and the most powerful medical intervention in the control, prevention and eradication of many diseases that affect human population. Capsular polysaccharide based vaccines have been in use for many decades providing immunity against various bacterial infections. The advent of new efficient and sensitive analytical and synthetic methods in carbohydrate chemistry, together with our increased understanding of glycobiology and glycoimmunology, makes the development of carbohydrate based vaccines against various cancers possible. This review article describesthe biological basis of vaccination and summarizes the recent progress in the development of carbohydrate based glycoconjugate vaccines with particular emphasis on structure, function and chemistry of glycoconjugates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 11:11:48