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Titolo:
Effect of gonadotrophin-releasing hormone (GnRH) antagonist during the LH surge in normal women and during controlled ovarian hyperstimulation
Autore:
Christin-Maitre, S; Olivennes, F; Dubourdieu, S; Chabbert-Buffet, N; Charbonnel, B; Frydman, R; Bouchard, P;
Indirizzi:
Hop St Antoine, Serv Endocrinol, F-75012 Paris, France Hop St Antoine Paris France F-75012 rv Endocrinol, F-75012 Paris, France Hop Antoine Beclere, Serv Gynecol Obstet, Clamart, France Hop Antoine Beclere Clamart France Serv Gynecol Obstet, Clamart, France Hotel Dieu, Clin Endocrinol, Nantes, France Hotel Dieu Nantes FranceHotel Dieu, Clin Endocrinol, Nantes, France
Titolo Testata:
CLINICAL ENDOCRINOLOGY
fascicolo: 6, volume: 52, anno: 2000,
pagine: 721 - 726
SICI:
0300-0664(200006)52:6<721:EOGH(A>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NAL-GLU; PERIOVULATORY PERIOD; MENSTRUAL-CYCLE; CORPUS-LUTEUM; CETRORELIX; SECRETION; SUPPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Christin-Maitre, S Hop St Antoine, Serv Endocrinol, 184 Rue Faubourg St Antoine, F-75012 Paris, France Hop St Antoine 184 Rue Faubourg St Antoine Paris France F-75012
Citazione:
S. Christin-Maitre et al., "Effect of gonadotrophin-releasing hormone (GnRH) antagonist during the LH surge in normal women and during controlled ovarian hyperstimulation", CLIN ENDOCR, 52(6), 2000, pp. 721-726

Abstract

OBJECTIVE Several studies have suggested that GnRH is instrumental in triggering the LH surge. The present studies were performed to evaluate the effect of GnRH antagonist administration in women after the beginning of the LH surge. DESIGN In study one, six normal cycling women were given a GnRH antagonist(20 mg Nal Glu s.c.) during an unstimulated cycle. Nal-Glu was administered when the LH level was higher than 10 U/l and associated with an oestradiol (E2) level higher than 730 pmol/l. In study two, a GnRH antagonist (3 mg Cetrorelix(R), ASTA-Medica, Frankfurt, Germany) was administered on day 8 of an IVF-ET cycle, in 157 women. Eighteen women among this cohort received the antagonist, when their LH level was higher than 10 U/l. RESULTS In normal volunteers (study one), Nal-Glu was administered on day 13.7 +/- 1.4 (mean +/- SD) of the cycle when the LH level was 13.7 +/- 3.5 U/l with an E2 plasma level reaching 980 +/- 131 pmol/l. Twenty-four hours after administration of the antagonist, the LH surge had been interrupted in all subjects; it was postponed in three of the women, and abolished in the remaining three. LH levels fell by 68.5%, E2 by 42% and FSH by 53.2%. In study two, LH plasma levels 24 h after the antagonist administration fell by 94%. No premature ovulation occurred in any of the patients treated. Administering the antagonist before (n = 139) or during the LH surge (n = 18) made no statistically significant difference to the results of the IVF-ET attempt. CONCLUSIONS Our results indicate that GnRH is required throughout the gonadotrophin surge in women, not only for the initiation but also for the maintenance of the LH surge. In addition, in our study, the suppression of the rise in LH, when the antagonist was given during the surge, had no detrimental impact on IVF-ET outcome. This suggests, if confirmed on a larger scale, that late follicular phase GnRH antagonist administration to prevent the LH surge in controlled ovarian hyperstimulation (COH) is a safe and useful treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 09:39:36