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Titolo:
Effect of nocistatin in pain modulation
Autore:
Zhao, CS; Sun, RQ; Li, BS; Wang, Y; Luo, F; Wang, XM; Chang, JK; Han, JS;
Indirizzi:
Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China Beijing Med Univ Beijing Peoples R China 100083 100083, Peoples R China Phoenix Pharmaceut Inc, Mt View, CA USA Phoenix Pharmaceut Inc Mt View CAUSA ix Pharmaceut Inc, Mt View, CA USA
Titolo Testata:
CHINESE SCIENCE BULLETIN
fascicolo: 8, volume: 45, anno: 2000,
pagine: 716 - 720
SICI:
1001-6538(200004)45:8<716:EONIPM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORPHANIN FQ; RAT; ALLODYNIA; PEPTIDE;
Keywords:
morphine; nociceptin; nocistatin; hyperalgesia; allodynia; neuropathic pain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Han, JS Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China Beijing Med Univ Beijing Peoples R China 100083 Peoples R China
Citazione:
C.S. Zhao et al., "Effect of nocistatin in pain modulation", CHIN SCI B, 45(8), 2000, pp. 716-720

Abstract

Using tail-flick latency as the nociceptive index and von Frey hair to measure the mechanical allodynia, the aim of the present study is to determinewhether nocistatin, injected intracerebroventricularly (i.c.v.), would reverse the anti-morphine effect of orphanin FQ (OFQ), and, injected i.c.v. orintrathecally (i.t.), would inhibit the mechanical allodynia in a L5 and L6 spinal nerve ligation model of neuropathic pain in rats. The results showthat i.c.v. injection of nocistatin produces no significant changes in theTFL, nor does it affect morphine analgesia, In addition, i.c.v. or i.t. nocistatin produces no significant changes in withdrawal threshold of the nerve-lesioned hind paw. However, nocistatin significantly reverses the antagonistic effect of OFQ on morphine analgesia when it was coinjected i.c.v. with OFQ. The results suggest that nocistatin can reverse the anti-morphine effect of OFQ in rat brain, but cannot inhibit the mechanical allodynia of neuropathic pain in rat brain and spinal cord.

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Documento generato il 05/04/20 alle ore 01:50:28