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Titolo:
Role of p53 in cell cycle regulation and apoptosis following exposure to proteasome inhibitors
Autore:
Chen, F; Chang, D; Goh, M; Klibanov, SA; Ljungman, M;
Indirizzi:
Univ Michigan, Dept Radiat Oncol, Div Canc Biol, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 rehens Canc, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Mol & Cellular Biol Program, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 iol Program, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Urol Sect, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 , Urol Sect, Ann Arbor, MI 48109 USA
Titolo Testata:
CELL GROWTH & DIFFERENTIATION
fascicolo: 5, volume: 11, anno: 2000,
pagine: 239 - 246
SICI:
1044-9523(200005)11:5<239:ROPICC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-DAMAGE; NUCLEAR EXPORT; HUMAN FIBROBLASTS; RAPID DEGRADATION; INDUCE APOPTOSIS; TUMOR-SUPPRESSOR; RNA-POLYMERASE; MDM2; PHOSPHORYLATION; PATHWAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Ljungman, M Univ Michigan, Dept Radiat Oncol, Div Canc Biol, Ctr Comprehens Canc, 4306CCGC,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan 4306 CCGC,1500 E Med Ctr Dr Ann Arbor MI USA 48109
Citazione:
F. Chen et al., "Role of p53 in cell cycle regulation and apoptosis following exposure to proteasome inhibitors", CELL GROWTH, 11(5), 2000, pp. 239-246

Abstract

In this study, we explored what effect inhibitors of the 26S proteasome have on cell cycle distribution and induction of apoptosis in human skin fibroblasts and colon cancer cells differing in their p53 status. We found thatproteasome inhibition resulted in nuclear accumulation of p53. This was surprising because it is thought that the degradation of p53 is mediated by cytoplasmic 26S proteasomes. Nuclear accumulation of p53 was accompanied by the induction of both p21(WAF1) mRNA and protein as well as a decrease in cells entering S phase. Interestingly, cells with compromised p53 function showed a marked increase in the proportion of cells in the G(2)-M phase of the cell cycle end an attenuated induction of apoptosis after proteasome inhibition. Taken together, our results suggest that proteasome inhibition results in nuclear accumulation of p53 and a p53-stimulated induction of both G(1) arrest and apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 12:55:06