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Titolo:
Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity
Autore:
Schmucker, D; Clemens, JC; Shu, H; Worby, CA; Xiao, J; Muda, M; Dixon, JE; Zipursky, SL;
Indirizzi:
Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 t Biol Chem, Ann Arbor, MI 48109 USA Univ Calif Los Angeles, Sch Med, Dept Biol Chem, Howard Hughes Med Inst, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
CELL
fascicolo: 6, volume: 101, anno: 2000,
pagine: 671 - 684
SICI:
0092-8674(20000609)101:6<671:DDIAAG>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH CONE GUIDANCE; ADAPTER PROTEIN; GENETIC-ANALYSIS; NERVOUS-SYSTEM; MECHANISMS; CADHERINS; REGION; KINASE; DOCK; CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Dixon, JE Univ Michigan, Dept Biol Chem, 1301 E Catherine, Ann Arbor, MI 48109 USA Univ Michigan 1301 E Catherine Ann Arbor MI USA 48109 48109 USA
Citazione:
D. Schmucker et al., "Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity", CELL, 101(6), 2000, pp. 671-684

Abstract

A Drosophila homolog of human Down syndrome cell adhesion molecule (DSCAM), an immunoglobulin superfamily member, was isolated by its affinity to Dock, an SH3/SH2 adaptor protein required for axon guidance. Dscam binds directly to both Dock's SH2 and SH3 domains. Genetic studies revealed that Dscam, Dock and Pak, a serine/threonine kinase, act together to direct pathfinding of Bolwig's nerve, containing a subclass of sensory axons, to an intermediate target in the embryo. Dscam also is required for the formation of axon pathways in the embryonic central nervous system. cDNA and genomic analyses reveal the existence of multiple forms of Dscam with a conserved architecture containing variable Ig and transmembrane domains. Alternative splicing can potentially generate more than 38,000 Dscam isoforms. This molecular diversity may contribute to the specificity of neuronal connectivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 11:33:37